The clinico-functional examination of agricultural machine-operators, truck drivers, excavator and boring machine operators revealed that, under low-frequency general vibration, polymorphic pathologic changes occur in human organism. Those include peripheral vascular and neuritic disorders and changes in the vertebral column. The most peculiar symptoms of VD are dealt with. The data obtained show to the importance of further elaboration of differential diagnostic criteria of VD, specifying its pathogenic mechanisms and prevention measures working out.

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