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miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma. | LitMetric

AI Article Synopsis

  • Malignant pleural mesothelioma (MPM) is a serious cancer linked to asbestos exposure, characterized by altered microRNA expression, particularly in miR-192 and miR-193a-3p.
  • Significant reductions in miR-193a-3p (3.1-fold) and miR-192 (2.8-fold) were observed in MPM tumors compared to normal pleura, indicating a potential role in disease progression.
  • Introducing miR-193a-3p into MPM cells decreased their growth and promoted cell death, and using EDV minicells for targeted delivery of miR-193a-3p in tumor models showcased its potential as a therapeutic strategy.

Article Abstract

Malignant pleural mesothelioma (MPM) is an asbestos-induced cancer with poor prognosis that displays characteristic alterations in microRNA expression. Recently it was reported that the expression of a subset of microRNAs can distinguish between MPM and adenocarcinoma of the lung. However, the functional importance of these changes has yet to be investigated. We compared expression of miR-192, miR-193a-3p and the miR-200 family in normal pleura and MPM tumor specimens and found a statistically significant reduction in the levels of miR-193a-3p (3.1-fold) and miR-192 (2.8-fold) in MPM. Transfection of MPM cells with a miR-193a-3p mimic resulted in inhibition of growth and an induction of apoptosis and necrosis in vitro. The growth inhibitory effects of miR-193a-3p were associated with a decrease in MCL1 expression and were recapitulated by RNAi-mediated MCL1 silencing. Targeted delivery of miR-193a-3p mimic using EDV minicells inhibited MPM xenograft tumour growth, and was associated with increased apoptosis. In conclusion, miR-193a-3p appears to have importance in the biology of MPM and may represent a target for therapeutic intervention.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695131PMC
http://dx.doi.org/10.18632/oncotarget.4346DOI Listing

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