Infections with Halicephalobus nematodes, causative agents of severe meningoencephalitis in horses, have rarely been reported in humans. In this study, the clinical, serological, cytokine, and histopathological findings of a rapidly progressive and eventually fatal meningoencephalitis in a previously healthy human are described. The helminth was finally diagnosed by specific polymerase chain reactions from post mortem tissue.
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http://dx.doi.org/10.1093/ofid/ofv061 | DOI Listing |
Commun Biol
September 2024
Biology Department, American University, 4400 Massachusetts Avenue, NW, Washington, DC, 20016, USA.
In this study, we report a biological temperature-sensing electrical regulator in the cytochrome c oxidase of the Devil Worm, Halicephalobus mephisto. This extremophile metazoan was isolated 1.3 km underground in a South African goldmine, where it adapted to heat and potentially to hypoxia, making its mitochondrial sequence a likely target of adaptational change.
View Article and Find Full Text PDFSci Rep
July 2024
Laboratory of Agricultural Microbiology, Instituto Federal Goiano - campus Rio Verde, Highway Sul Goiana, Km 01, Rio Verde, GO, 75901-970, Brazil.
Medicinal plant microbiomes undergo selection due to secondary metabolite presence. Resident endophytic/epiphytic microorganisms directly influence plant's bioactive compound synthesis. Hypothesizing low microbial diversity in Serjania erecta leaves, we assessed leaf colonization by epiphytic and endophytic fungi.
View Article and Find Full Text PDFParasites Hosts Dis
February 2024
Department of Veterinary Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul State 79070-900, Brazil.
Halicephalobus gingivalis is a free-living nematode that occasionally causes infections in horses. We report a rare case of limb fracture of horse caused by infection with H. gingivalis.
View Article and Find Full Text PDFActa Vet Scand
December 2023
Department of Microbiology, National Veterinary Institute (SVA), Uppsala, Sweden.
Background: Halicephalobus gingivalis is a nematode with zoonotic potential which can cause fatal opportunistic infections in various mammals. The parasite has never been diagnosed in Sweden, in any species, prior to the presented case.
Case Presentation: An imported 21-year-old Icelandic mare developed severe neurological signs.
Vet Res Commun
February 2024
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Background: Parasitic infections pose significant threats to humans' and animals' well-being worldwide. Among these parasites, Halicephalobus spp., a genus of nematodes, has gained attention due to its ability to cause severe infections in various animal species, including horses.
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