The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464267 | PMC |
http://dx.doi.org/10.3762/bjoc.11.74 | DOI Listing |
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