Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

Beilstein J Org Chem

Laboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg, France ; Institut Universitaire de France, 103 Bd Saint-Michel, 75005 Paris, France.

Published: June 2015

The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464267PMC
http://dx.doi.org/10.3762/bjoc.11.74DOI Listing

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