AI Article Synopsis
- The study aimed to find the best cut-off values for basal (bCT) and peak stimulated calcitonin (psCT) levels to differentiate between medullary thyroid carcinoma (MTC) and C-cell hyperplasia (CCH).
- Out of 55 patients with high psCT levels, 20 were diagnosed with MTC, while 35 had CCH, with a bCT level over 17.4 pg/ml and psCT level over 452 pg/ml being the most effective in distinguishing the two conditions.
- The results highlight that overlapping calcitonin levels can make diagnostic accuracy challenging, and some patients with high psCT levels may actually have differentiated thyroid carcinoma of different origins.
Article Abstract
Background/aim: Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin-secreting tumor. Calcitonin is also elevated in C-cell hyperplasia (CCH). The objective of the study was to determine the optimal basal (bCT) and peak stimulated calcitonin (psCT) cut-off value for differentiating MTC from CCH, and to examine the histological findings of thyroidectomy in patients with maximum psCT >100 pg/ml.
Patients And Methods: Fifty-five patients had a maximum calcium-psCT >100 pg/ml and underwent total thyroidectomy.
Results: A total of 20 patients were diagnosed with MTC and the remaining 35 with CCH. A bCT level >17.4 pg/ml and psCT level >452 pg/ml demonstrated the best sensitivity and positive predictive value for differenting MTC from CCH.
Conclusion: The overlap of calcitonin levels between MTC and CCH reduces the accuracy of the calcium stimulation test. Remarkably, an appreciable number of patients with psCT levels >100 pg/ml harbor differentiated thyroid carcinoma of follicular origin.
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