Cilia are cellular projections that perform sensory and motile functions. A key ciliary subdomain is the transition zone, which lies between basal body and axoneme. Previous work in Caenorhabditis elegans identified two ciliopathy-associated protein complexes or modules that direct assembly of transition zone Y-links. Here, we identify C. elegans CEP290 as a component of a third module required to form an inner scaffolding structure called the central cylinder. Co-inhibition of all three modules completely disrupted transition zone structure. Surprisingly, axoneme assembly was only mildly perturbed. However, dendrite extension by retrograde migration was strongly impaired, revealing an unexpected role for the transition zone in cell adhesion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493997 | PMC |
| http://dx.doi.org/10.1083/jcb.201501013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Strengthening Mechanism of Alkali Curing on Mechanical Properties of Fly Ash Lightweight Aggregates and Its Concrete.
Materials (Basel)
December 2024
Jiangsu Key Laboratory Environmental Impact and Structural Safety in Engineering, China University of Mining and Technology, Xuzhou 221116, China.
The low hydration degree of fly ash in Fly Ash Unburned Lightweight Aggregate (FULA) is not conducive to the development of the mechanical properties of lightweight aggregates and their concrete. In this paper, FULA was immersed in an alkaline solution with the purpose of improving the mechanical properties of FULA and its concrete. Firstly, FULA was prepared using fly ash as the main raw material.
View Article and Find Full Text PDFThermally Induced Phenomena in Amorphous Nifedipine: The Correlation Between the Structural Relaxation and Crystal Growth Kinetics.
Molecules
January 2025
Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, nam. Cs Legii 565, 532 10 Pardubice, Czech Republic.
The particle size-dependent processes of structural relaxation and crystal growth in amorphous nifedipine were studied by means of non-isothermal differential scanning calorimetry (DSC) and Raman microscopy. The enthalpy relaxation was described in terms of the Tool-Narayanaswamy-Moynihan model, with the relaxation motions exhibiting the activation energy of 279 kJ·mol for the temperature shift, but with a significantly higher value of ~500 kJ·mol being obtained for the rapid transition from the glassy to the undercooled liquid state (the latter is in agreement with the activation energy of the viscous flow). This may suggest different types of relaxation kinetics manifesting during slow and rapid heating, with only a certain portion of the relaxation motions occurring that are dependent on the parameters of a given temperature range and time frame.
View Article and Find Full Text PDFMetastable state preceding shear zone instability: Implications for earthquake-accelerated landslides and dynamic triggering.
Proc Natl Acad Sci U S A
January 2025
Institut Langevin, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Université Paris Sciences & Lettres, CNRS, Paris 7587, France.
Understanding the dynamic response of granular shear zones under cyclic loading is fundamental to elucidating the mechanisms triggering earthquake-induced landslides, with implications for broader fields such as seismology and granular physics. Existing prediction methods struggle to accurately predict many experimental and in situ landslide observations due to inadequate consideration of the underlying physical mechanisms. The mechanisms that influence landslide dynamic triggering, a transition from static (or extremely slow creeping) to rapid runout, remain elusive.
View Article and Find Full Text PDFThe return of stagnant slab recorded by intraplate volcanism.
Proc Natl Acad Sci U S A
January 2025
State Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Xi'an 710069, China.
Subducted plates often stagnate in the mantle transition zone (MTZ), and the fate of the stagnant slabs is still debatable. They may sink into the lower mantle, or remain partially trapped in the MTZ, but it is uncertain whether they can return to the upper mantle. We report geochemical evidence of late-Miocene (~6 Ma) basalts from, and upper mantle seismic evidence beneath Shuangyashan, an area above the slab tear of the stagnant Pacific plate in eastern Asia, to show how the slab returns to the upper mantle from the MTZ.
View Article and Find Full Text PDFUltrasound-guided Transperineal Prostate Thermal Ablation (TPTA) for Benign Prostatic Hyperplasia: Feasibility of an Outpatient Procedure using Radiofrequency Ablation.
Cardiovasc Intervent Radiol
January 2025
Department of Radiology, Universidade Federal de São Paulo (UNIFESP), Rua Dr. Ovidio Pires de Campos, 75, Cerqueira César, São Paulo, SP, 05403-010, Brazil.
Purpose: To evaluate the feasibility, safety, and short-term (3-month) results of transperineal prostate thermal ablation (TPTA) as a minimally invasive outpatient treatment for benign prostatic hyperplasia (BPH).
Materials And Methods: A prospective nonrandomized study of 25 patients with lower urinary tract symptoms secondary to BPH seeking care at 2 interventional radiology centers between March and July 2024. TPTA was performed using a 17G radiofrequency needle with a 10-mm active tip under unconscious sedation combined with bilateral perineal and periprostatic nerve blocks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!