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Decompensated Cirrhosis with Hepatopulmonary Syndrome in a Patient with Interrupted Treatment for Hypopituitarism: A Case Report.
Intern Med
January 2025
Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Japan.
A 32-year-old man presented with cirrhosis. At 8 years of age, he underwent resection of a craniopharyngioma, which resulted in panhypopituitarism. He underwent self-interrupted hormone replacement therapy at 20 years of age.
View Article and Find Full Text PDFCavitating Osmotic Demyelination Syndrome Following Correction of Chronic Hyponatremia in Sheehan's Syndrome: A Novel Case Report.
Neurohospitalist
September 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
Article Synopsis
- Rapid correction of chronic hyponatremia can lead to osmotic demyelination syndrome (ODS), especially in patients with underlying conditions like Sheehan’s syndrome, a rare pituitary disorder following severe postpartum hemorrhage.
- A case report details a 40-year-old woman who experienced neurological decline due to the correction of her long-standing hyponatremia, which had been mismanaged for years, leading to extrapontine and then central pontine myelinolysis.
- The case emphasizes that even gradual correction of low sodium levels poses risks and highlights the need for careful management in patients with chronic hyponatremia and related conditions.
Deciphering craniopharyngioma subtypes: Single-cell analysis of tumor microenvironment and immune networks.
iScience
November 2024
Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba, Japan.
Craniopharyngiomas, including adamantinomatous (ACP) and squamous papillary (PCP) types, are challenging to treat because of their proximity to crucial pituitary structures. This study aimed to characterize the cellular composition, tumor tissue diversity, and cell-cell interactions in ACPs and PCPs using single-cell RNA sequencing. Single-cell clustering revealed diverse cell types, further classified into developing epithelial, calcification, and immune response for ACP and developing epithelial, cell cycle, and immune response for PCP, based on gene expression patterns.
View Article and Find Full Text PDFMyxedema Coma as a Presentation of Panhypopituitarism Secondary to Traumatic Brain Injury.
Case Rep Endocrinol
October 2024
Department of Endocrinology and Nutrition, Central University Hospital of Asturias/University of Oviedo, Oviedo, Spain.
Article Synopsis
- Myxedema coma often involves reduced consciousness and low body temperature, potentially linked to thyroid issues, especially in patients with head trauma and central hormone deficiencies.
- A 52-year-old man with head trauma exhibited symptoms like drowsiness and hypotension, with initial tests showing normal TSH levels but low ACTH and FT4, and his condition worsened before improving with medication.
- The case highlights the importance of assessing both TSH and FT4 levels for diagnosing central hypothyroidism, as relying solely on TSH might lead to overlooked conditions in patients showing hormone deficiency symptoms post-trauma.
A young woman with unexpected panhypopituitarism: Case Report.
SAGE Open Med Case Rep
October 2024
Augusta University Medical College of Georgia, Augusta, GA, USA.
Article Synopsis
- - A 25-year-old woman with type II diabetes experienced severe nausea and vomiting, along with significant weight loss over 5 weeks, despite normal vital signs and extensive gastrointestinal testing.
- - Further investigation revealed panhypopituitarism, a rare condition causing deficiencies in multiple pituitary hormones, particularly adrenocorticotropic hormone and cortisol, which were linked to her symptoms.
- - After starting treatment for panhypopituitarism, her symptoms resolved within 24 hours, underscoring the importance of thorough medical history and examination in diagnosing rare conditions.
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