Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404 | PMC |
| http://dx.doi.org/10.1038/nn.4054 | DOI Listing |
Publication Analysis
Top Keywords
nuclear pore
8
pore complex
8
tgf-β signaling
8
complex remodeling
4
p75ntr
4
remodeling p75ntr
4
p75ntr cleavage
4
cleavage controls
4
controls tgf-β
4
signaling astrocyte
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!