The effects of sesame oil on the prevention of amiodarone-induced phlebitis.

Iran J Nurs Midwifery Res

Department of Biostatistics and Epidemiology, Psychiatry and Behavioral Sciences Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.

Published: June 2015

AI Article Synopsis

  • The study investigates the effectiveness of sesame oil in preventing phlebitis, a common complication from amiodarone infusion.
  • It involved a double-blind randomized trial with 36 patients, where one group received sesame oil and the other a placebo (liquid paraffin) during amiodarone administration.
  • Results indicated that a higher percentage of patients using sesame oil (61.1%) did not develop phlebitis compared to the control group, showcasing a significant reduction in phlebitis incidence.

Article Abstract

Background: Phlebitis is the most common complication associated with peripheral intravenous infusion of amiodarone. The purpose of this study is to determine the effects of sesame oil on the prevention of amiodarone-induced phlebitis.

Materials And Methods: This is a double-blind randomized controlled trial. Thirty-six patients hospitalized in a coronary care unit were randomly allocated into two groups using a convenience sampling method. Following peripheral intravenous cannulation, five drops of pure sesame oil were applied to the skin within a 10 cm radius of the infusion site prior to the administration of amiodarone in the intervention group. Sesame oil was rubbed on the skin at the infusion site every 6 h in the 24-h period of amiodarone infusion. In the control group, liquid paraffin, used as a placebo, was rubbed on the skin at the infusion site of amiodarone. Both groups were monitored for the development of phlebitis and its degree within the 24-h period of amiodarone infusion as well as 6 h after its administration. The incidence of phlebitis was confirmed and recorded by an assessor who was blind to the two groups. Data were analyzed using Statistical Package for Social Science (SPSS) version 18, and descriptive and inferential statistics such as Chi-square test, Kaplan-Meier, Hazard ratio, independent t-test, and Fisher's exact test.

Results: There was a statistically significant difference between the two groups in their catheter survival after 30 h and 10 min (P < 0.001). Over 60% of the patients (61.1%) in the intervention group did not show any sign of phlebitis, while 16.7% and 22.2% of the patients manifested signs of grade 2 and 3 phlebitis, respectively. In the control group, 22.2% of the patients showed no signs of phlebitis, while 5.6%, 27.8%, and 44.4% of the patients exhibited signs of grade 2, 3, and 4 phlebitis, respectively. The statistical analysis showed significant differences in the degree of phlebitis (P = 0.006) and the onset of phlebitis development (P < 0.001) between the two groups.

Conclusions: It is recommended to apply sesame oil topically to the infusion site of amiodarone so as to reduce the rate of the development of amiodarone-related phlebitis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462063PMC

Publication Analysis

Top Keywords

sesame oil
20
infusion site
16
phlebitis
11
effects sesame
8
oil prevention
8
prevention amiodarone-induced
8
peripheral intravenous
8
intervention group
8
rubbed skin
8
skin infusion
8

Similar Publications

Sesamol is a significant lignan in sesame oil, which can be converted from sesamolin under acid-catalyzed conditions. The effects of several factors on the conversion of sesamolin to sesamol under acid-catalyzed conditions were investigated. The conversion kinetics were studied and the relevant conversion mechanism was revealed by density functional theory (DFT).

View Article and Find Full Text PDF

The process of micromachining has garnered attention for its ability to create three-dimensional tiny features, particularly in ultra-hard and exotic materials. The present work investigates the effect of different parameters of the µ-ED milling, such as pulse on time (Ton), pulse off time (Toff), voltage (V), and tool rotation (TR) on the dimensional deviation (DD), material removal rate (MRR), surface roughness (Ra), and machined surface characteristics (analysed by EDS and FESEM). The sesame oil as dielectric and tungsten-copper as tool electrodes were used to maintain the accuracy and improve the machinability of bio-grade Nitinol SMA.

View Article and Find Full Text PDF

Sesame (Sesamum indicum L., 2n = 2× = 26) from the Pedaliaceae family is primarily grown for its high oil content, rich in unsaturated fatty acids like linoleic acid (LA) and alpha-linolenic acid (ALA). However, the molecular mechanisms of sesame oil accumulation remain poorly understood.

View Article and Find Full Text PDF

Seed cycling therapy (SCT) involves the consumption of specific seeds during the follicular and luteal phases of the menstrual cycle to help balance reproductive hormones. This study aimed to investigate the effects of SCT on healthy female Wistar albino rats to prevent hormonal imbalances. For SCT, a seed mixture (SM1) consisting of flax, pumpkin, and soybeans (estrogenic seeds) was administered at doses of 5.

View Article and Find Full Text PDF

Extraction and characterization of spherical nanocellulose from sesame husks.

Heliyon

January 2025

Department of Food Engineering Technologies, Faculty of Technical Engineering, Aleppo University, Syria.

The objective of this study was to extract and characterize nanocellulose from sesame husks, which are typically discarded as waste by sesame processing facilities. However, these husks are rich in cellulose, presenting a valuable potential source for nanocellulose. Sesame husk cellulose (SHC) was initially isolated through a multi-step process that removed oil, hemicellulose, and lignin.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!