Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole and bis(indolyl)methanes derivatives and were synthesized using this methodology. Compound is an intermediary in the synthesis of the natural bisindoles arsindoline and streptindole . The structure of vibrindole was unequivocally confirmed by a single crystal X-ray diffraction analysis.
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| http://dx.doi.org/10.2174/1570178612666150220225335 | DOI Listing |
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