From rhizomes of Panax japonicus (Araliaceae), two polysaccharides named tochibanan-A and -B, which show reticuloendothelial-potentiating activity in the carbon clearance test in mice, were isolated. The structure of tochibanan-A (molecular mass: 23,000) was elucidated as a linear beta-1,4-D-galactan. Tochibanan-B (molecular mass: 40,000) consists of D-galactose (87.1%), L-arabinose, D-glucose and D-galacturonic acid and has a beta-D-(1----4)-linked galactopyranosyl backbone possessing GalA-(1----6)-Gal, Ara-(1----5)-Ara, Gal, and Glc side chains. The structure around the branching points and the repeating unit were investigated and a possible structure of tochibanan-B is proposed.
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http://dx.doi.org/10.1248/cpb.37.2587 | DOI Listing |
Chin J Nat Med
January 2025
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. Electronic address:
Astragali Radix (AR) and Notoginseng Radix et Rhizoma (NR) are frequently employed in cardiovascular disease treatment. However, the efficacy of the AR-NR medicine pair (AN) in improving cardiac remodeling and its underlying mechanism remains unclear. This study aimed to evaluate AN's cardioprotective effect and potential mechanism on cardiac remodeling using transverse aortic constriction (TAC) in mice and angiotensin II (Ang II)-induced neonatal rat cardiomyocytes (NRCMs) and fibroblasts in vitro.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
October 2024
Chinese Pharmacopoeia Commission Beijing 100061, China.
Ginseng Radix et Rhizoma and its preparations are often adulterated with Panacis Quinquefolii Radix. Based on the research on Ginseng Radix et Rhizoma and Panacis Quinquefolii Radix, the causes and analytical method of adulteration were determined. A UPLC-MS/MS method was developed for the detection of Panacis Quinquefolii Radix mixed in Ginseng Radix et Rhizoma, with pseudoginsenoside F_(11) as the marker.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
Haihe Laboratory of Modern Chinese Medicine, 10 Poyanghu Road, Tianjin 301617, China.
Ginsenosides and lipids are both bioactive ingredients for ginseng. Targeting these two categories of components, this study was designed to develop desorption electrospray ionization-mass spectrometry imaging approaches and spatial metabolomics strategies, achieving the visualization and differentiation among different parts of root (e.g.
View Article and Find Full Text PDFPLoS One
November 2024
Department of Pharmacognosy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Curr Issues Mol Biol
October 2024
Co-constructing Key Laboratory by Province and the Ministry of Science and Technology of Ecological Restoration and Ecosystem Management, College of Chinese Medicinal Material, Jilin Agricultural University, Changchun 130118, China.
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