The features of the course of exacerbations of chronic obstructive pulmonary disease (COPD) in combination with coronary heart disease in the form of stable angina, and with the threat of destabilizing its course. The changes of the cardiovascular system in patients with a background of clinical symptoms in patients with acute exacerbation of COPD II-III stages. A differentiated approaches to anti-inflammatory and cardio protective action of drug combinations Roflumilast and quercetin as components of adjuvant therapy in patients with combined cardiovascular disease.

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