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Is ChatGPT ready for public use in organ-specific drug toxicity research?
Drug Discov Today
January 2025
National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:
The growing impact of large language models (LLMs), such as ChatGPT, prompts questions about the reliability of their application in public health. We compared drug toxicity assessments by GPT-4 for liver, heart, and kidney against expert assessments using US Food and Drug Administration (FDA) drug-labeling documents. Two approaches were assessed: a 'General prompt', mimicking the conversational style used by the general public, and an 'Expert prompt' engineered to represent an approach of an expert.
View Article and Find Full Text PDFInsights from social media into public perspectives on investigative genetic genealogy.
Front Genet
January 2025
Baylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, TX, United States.
Social media sites like X (formerly Twitter) increasingly serve as spaces for the public to discuss controversial topics. Social media can spark extreme viewpoints and spread biased or inaccurate information while simultaneously allowing for debate around policy-relevant topics. The arrest of Joseph J.
View Article and Find Full Text PDFDetermining timeframes to death for imminently dying patients: a retrospective cohort study.
BMC Palliat Care
January 2025
Caring Futures Institute, Flinders University, Sturt Rd, Bedford Park, Adelaide, South Australia, 5042, Australia.
Background: Clinicians are frequently asked 'how long' questions at end-of-life by patients and those important to them, yet predicting timeframes to death remains uncertain, even in the last weeks and days of life. Patients and families wish to know so they can ask questions, plan, make decisions, have time to visit and say their goodbyes, and have holistic care needs met. Consequently, this necessitates a more accurate assessment of empirical data to better inform prognostication and reduce uncertainty around time until death.
View Article and Find Full Text PDFAn Eye Tracker Study on the Understanding of Implicitness in French Elementary School Children.
Brain Sci
November 2024
ISJPS UMR 8103 CNRS, Université Paris 1 Panthéon Sorbonne, 75005 Paris, France.
Background: The aim of this study is to use an eye tracker to compare the understanding of three forms of implicitness (i.e., presupposition, conversational implicatures, and irony) in 139 pupils from the first to the fifth year of elementary school.
View Article and Find Full Text PDFThe Role of Friendship in Mediating and Moderating the Relationship Between Exposure to Gendered Racism and Mental Health among Young Women of Color.
J Youth Adolesc
January 2025
Department of Psychology, Fordham University, 441 East Fordham Road, Dealy Hall, Bronx, NY, USA.
Young women of color frequently face discrimination, reflecting the intersecting societal influences of sexism and racism. Although friendships play a significant role in women's lives, there is a lack of research on the role of friendships in navigating exposure to gendered racial discrimination (in-person and social media) and associated mental health. This study investigated the extent to which the content of friendship conversations (i.
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