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Molecular dynamics simulations to decipher the hotspots at the allosteric site of human 5-lipoxygenase.
J Mol Graph Model
January 2025
Molecular Modeling and Protein Engineering Lab, Biology Division, Department of Humanities and Sciences, Indian Institute of Petroleum and Energy, Visakhapatnam, Andhra Pradesh, 530003, India. Electronic address:
Human 5-lipoxygenase (LOX) is a non-heme, Fe-containing LOX which catalyses the conversion of arachidonic acid (AA) to leukotriene A (LTA). LTA is subsequently converted to cysteinyl-LTs and LTB that cause bronchoconstriction and act as chemotactic and chemokinetic agent on human leukocytes, respectively. Leukotrienes play significant roles in inflammation in asthma, cardiovascular diseases, allergic rhinitis, atopic dermatitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis and many more.
View Article and Find Full Text PDFThe A-Z of age-related dermatological diseases.
Br J Community Nurs
January 2025
Freelance medical writer and journalist.
Skin ageing is an inevitable process influenced by both intrinsic and extrinsic factors. Intrinsic aging leads to thinner, drier and less elastic skin with fine wrinkles, while extrinsic factors such as sun exposure, smoking and environmental stresses amplify these changes. Photo-ageing, in particular, causes deep wrinkles, uneven pigmentation and increases the risk of skin cancers.
View Article and Find Full Text PDFGuided monocyte fate to FRβ/CD163 S1 macrophage antagonises atopic dermatitis via fibroblastic matrices in mouse hypodermis.
Cell Mol Life Sci
December 2024
Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Macrophages are versatile myeloid leukocytes with flexible cellular states to perform diverse tissue functions beyond immunity. This plasticity is however often hijacked by diseases to promote pathology. Scanning kinetics of macrophage states by single-cell transcriptomics and flow cytometry, we observed atopic dermatitis drastically exhausted a resident subtype S1.
View Article and Find Full Text PDFAdvances of the exposome at individual levels and prevention in atopic dermatitis.
Int J Dermatol
December 2024
Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY, USA.
Article Synopsis
- Atopic dermatitis (AD), commonly known as eczema, is an inflammatory skin condition influenced by various environmental factors and characterized by its complex forms and symptoms.
- Intrinsic and extrinsic factors, including allergens, microorganisms, diet, and psychological stress, play significant roles in the development and severity of AD, with growing attention on how skin microorganisms affect skin health.
- Understanding the intricate interactions between host, microbes, and the environment is essential for developing effective primary prevention strategies for AD, but current preventive measures related to diet and microorganisms are still debated.
Decoy oligodeoxynucleotides: A promising therapeutic strategy for inflammatory skin disorders.
Hum Immunol
November 2024
Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD) impose a significant burden on both the skin and the overall well-being of individuals, leading to a diminished quality of life. Despite the use of conventional treatments like topical steroids, there remains a need for more effective and safer therapeutic options to improve the lives of patients with severe skin conditions. Molecular therapy has emerged as a promising approach to address disorders such as atopic dermatitis, psoriasis, and contact hypersensitivity.
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