As a widespread phenomenon in living system, molecular self-assembly has become the meeting point of multidisciplinary research including chemistry, biology, materials science and medicine. In recent years, the rapid development in molecular self-assembly of peptide technology is showing a great potential in the application of tissue engineering, drug delivery, bionic medicine, cosmetology field, optical and electronic product development, etc. Especially, the remarkable hemostatic effect of self-assembling peptides (SAP) on organs, nerves and brain wounds successfully promoted its application to the material science and clinical medicine. This review focuses on the hemostatic effects and characteristics of SAP on different bleeding wound models, action mechanism, its benefits and limitations as well as its adrancing trends.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.7534/j.issn.1009-2137.2015.03.058 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peptide-Perovskite Based Bio-Inspired Materials for Optoelectronics Applications.
Adv Sci (Weinh)
January 2025
BCMaterials, Basque Center for Materials, Applications, and Nanostructures, UPV/EHU Science Park, Leioa, 48940, Spain.
The growing demand for environmentally friendly semiconductors that can be tailored and developed easily is compelling researchers and technologists to design inherently bio-compatible, self-assembling nanostructures with tunable semiconducting characteristics. Peptide-based bioinspired materials exhibit a variety of supramolecular morphologies and have the potential to function as organic semiconductors. Such biologically or naturally derived peptides with intrinsic semiconducting characteristics create new opportunities for sustainable biomolecule-based optoelectronics devices.
View Article and Find Full Text PDFA Novel Polymersome Nanocarrier Promotes Anti-Tumour Immunity by Improved Priming of CD8 T Cells.
Immunology
January 2025
Singapore Immunology Network (SIgN), A*STAR, Singapore, Singapore.
Cancer is one of the leading causes of death worldwide. In recent years, immune checkpoint inhibitor therapies, in addition to standard immuno- or chemotherapy and surgical approaches, have massively improved the outcome for cancer patients. However, these therapies have their limitations and improved strategies, including access to reliable cancer vaccines, are needed.
View Article and Find Full Text PDFInfluence of Electrostatic Interactions on the Self-Assembly of Charged Peptides.
Gels
January 2025
Faculty of Medicine, Dalian University of Technology, Dalian 116033, China.
Peptides can be designed to self-assemble into predefined supramolecular nanostructures, which are then employed as biomaterials in a range of applications, including tissue engineering, drug delivery, and vaccination. However, current self-assembling peptide (SAP) hydrogels exhibit inadequate self-healing capacities and necessitate the use of sophisticated printing apparatus, rendering them unsuitable for 3D printing under physiological conditions. Here, we report a precisely designed charged peptide, Z5, with the object of investigating the impact of electrostatic interactions on the self-assembly and the rheological properties of the resulting hydrogels.
View Article and Find Full Text PDFSelf-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for Infection Treatment.
Gels
January 2025
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
, a prevalent zoonotic pathogen, poses a significant threat to skin wound infections. This study evaluates the bactericidal efficacy of self-assembled peptide hydrogels, PPI45 and PPI47, derived from the defensin-derived peptide PPI42, against ATCC43300. The high-level preparation of PPI45 and PPI47 was achieved with yields of 1.
View Article and Find Full Text PDFSelf-Assembling Peptides, Conjugates, and Mimics: A Versatile Platform for Materials and Beyond.
Acc Chem Res
January 2025
Pritzker School of Molecular Engineering, The University of Chicago, Chicago, Illinois 60637, United States.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!