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Stenotrophomonas maltophilia sepsis in preterm neonates.
Med J Armed Forces India
December 2024
Professor (Neonatology), Bharati Vidyapeeth Medical College, Deemed to be University, Pune, India.
, an environmentally ubiquitous microbe, is a challenging opportunistic pathogen in the hospital setting. Neonates are particularly vulnerable to infection with but information on presentation, therapeutic response and outcome of such infection in this population is limited. To expand this knowledge, we report here a series of five cases.
View Article and Find Full Text PDFNew Frontiers in Asthma Chest Imaging.
J Allergy Clin Immunol
December 2024
Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center. Electronic address:
Modern pulmonary imaging can reveal underlying pathological and pathophysiological changes in the lungs of people with asthma, with important clinical implications. A multitude of imaging modalities are now used to examine underlying structure/function relationships including computed tomography, magnetic resonance imaging, optical coherence tomography, and endobronchial ultrasound. Imaging-based biomarkers from these techniques, including airway dimensions, blood vessel volumes, mucus scores, ventilation defect extent and air trapping extent, often have increased sensitivity compared to traditional lung function measurements, and are increasingly used as endpoints in clinical trials.
View Article and Find Full Text PDF[Evolution of diagnostic criteria for allergic bronchopulmonary aspergillosis].
Zhonghua Jie He He Hu Xi Za Zhi
December 2024
Department of Respiratory and Critical Care, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha410008, China.
Article Synopsis
- - Allergic bronchopulmonary aspergillosis (ABPA) is a lung condition that leads to symptoms like wheezing and lung damage, but it often gets misdiagnosed due to its complex symptoms and lack of clear diagnostic guidelines.
- - Diagnostic criteria for ABPA have evolved over time, starting with the Rosenberg criteria in 1977, followed by improvements from ISHAM in 2013 and 2024, and new criteria for allergic bronchopulmonary mycosis (ABPM) introduced by Asano in 2021, which were found to be more sensitive.
- - Understanding and applying these updated diagnostic guidelines is important for better diagnosing and treating ABPA and ABPM, as misdiagnosis can lead
Article Synopsis
- Bronchopulmonary dysplasia (BPD) is a respiratory issue common in preterm infants that can worsen with pulmonary hypertension (PH), and this study explores the heart's left ventricle (LV) function in these cases.
- A study involving 80 infants under 28 weeks gestation found that those with BPD-PH had higher rates of significant heart issues, longer need for oxygen, and longer hospital stays, with distinct changes in LV function measured by tissue Doppler imaging.
- The study indicates that diagnosing BPD-PH could benefit from monitoring LV diastolic dysfunction, revealing a potential link between the function of the right and left ventricles in affected infants.
Development and validation of the prediction model based on autophagy-associated genes in bronchopulmonary dysplasia.
Ann Med
December 2024
Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Background: Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease among preterm infants. Owing to the limitations in current diagnostic methods, developing a predictive model for BPD is crucial.
Methods: Using 243 autophagy-associated genes and dataset GSE32472, differential expression of autophagy-associated genes was identified at postnatal days 5, 14, and 28 between BPD patients and controls.
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