AI Article Synopsis
- An algorithm has been developed to assess chromosome replication status, DNA synthesis rate per fork, and DNA quantity in chromosome equivalents for bacterial cells throughout their cell cycle.
- This algorithm is noteworthy as it is the first effort since the 1968 Cooper and Helmstetter model to analyze replication and G values based on cell age.
- To facilitate its application, two different implementations of the algorithm are provided.
Article Abstract
An algorithm is presented to determine the chromosome replication status, the rate of DNA synthesis per fork, and the amount of DNA in chromosome equivalents (G) per chromosome, per cell and per age throughout a bacterial cell cycle. This algorithm is the only attempt to study replication and the G value at any cell age since the general model of the bacterial cell cycle by Cooper and Helmstetter (1968, J. Mol. Biol. 31, 619-644). To help using it, two implementations are provided.
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| http://dx.doi.org/10.1016/j.jtbi.2015.06.008 | DOI Listing |
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