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Preterm birth in assisted reproduction: the mediating role of hypertensive disorders in pregnancy.
Hum Reprod
December 2024
Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Study Question: To what extent can hypertensive disorders in pregnancy (HDP) explain the higher risk of preterm birth following frozen embryo transfer (frozen-ET) and fresh embryo transfer (fresh-ET) in ART compared with naturally conceived pregnancies?
Summary Answer: HDP did not contribute to the higher risk of preterm birth in pregnancies after fresh-ET but mediated 20.7% of the association between frozen-ET and preterm birth.
What Is Known Already: Risk of preterm birth is higher after ART compared to natural conception.
Ventricular rupture during the removal of Impella 5.5 in a patient with fulminant myocarditis.
J Cardiol Cases
November 2024
Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
Unlabelled: Ventricular perforation or rupture caused by Impella (Abiomed Inc., Danvers, MA, USA) is extremely rare. The Japanese registry of Impella usage reported that the incidence of perforation was 0.
View Article and Find Full Text PDFExternal validation of SCORE2-Diabetes in the Netherlands across various Socioeconomic levels in native-Dutch and non-Dutch populations.
Eur J Prev Cardiol
November 2024
Department of Public Health and Primary Care/Health Campus the Hague, Leiden University Medical Center (LUMC), the Netherlands.
Aims: Adults with type 2 diabetes have an increased risk of cardiovascular events (CVE), the world's leading cause of mortality. The SCORE2-Diabetes model is a tool designed to estimate the 10-year risk of CVE specifically in individuals with type 2 diabetes. However, the performance of such models may vary across different demographic and socioeconomic groups, necessitating validation and assessment in diverse populations.
View Article and Find Full Text PDFEpistemic Risk Reduction in Psychedelic-Assisted Therapy.
Curr Top Behav Neurosci
November 2024
Centre for Philosophy and AI Research (PAIR), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Belief change is crucial to therapeutic benefit in psychedelic-assisted therapy as well as in more traditional forms of therapy. However, the use of psychedelics comes with a few unique challenges that require extra caution. First, drastic belief changes may occur faster than in regular therapy.
View Article and Find Full Text PDFInhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models.
Clin Transl Radiat Oncol
November 2024
Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboudumc, Nijmegen, the Netherlands.
Introduction: Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy resistance. It has been proposed that reducing the tumors' oxygen consumption will result in an increased oxygen concentration in the tissue and improve radio- and immunotherapy efficacy.
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