AI Article Synopsis
- - Nearly 15% of ovarian cancer patients have a germline BRCA mutation, prompting a pilot project in Genoa to evaluate the feasibility of offering genetic counseling during regular oncology visits for these patients.
- - In a review of records from 104 women with ovarian cancer, it was found that a significant number (94) had never received genetic counseling; of those, 31% were eventually referred for counseling, with a notable increase in referrals during initial visits compared to follow-ups.
- - Results showed that most referred patients (76%) attended genetic counseling, leading to a high rate of BRCA testing, with 19% of those tested identified as having BRCA1 mutations, highlighting the need for improved integration of genetic risk assessment in
Article Abstract
Background/aims: Nearly 15% of all ovarian cancer patients carry a germline BRCA mutation. A pilot project was started at IRCCS AOU San Martino--IST, Genoa, to assess the feasibility and consequences of offering genetic counselling to all ovarian cancer patients during routine oncology appointments. We present early results of this project.
Methods: Patients who attended an oncology visit at the Medical Oncology Unit 1 between November 2012 and December 2013 were identified. Medical records were reviewed for clinical data, genetic counselling and testing outcomes.
Results: Out of 104 women diagnosed with ovarian cancer undergoing an oncology visit, 94 had not had genetic counselling in the past. Twenty-nine patients (29/94, 31%) were referred to the Unit of Hereditary Cancer; of these, 14/26 (54%) were referred at the first visit and 15/68 (22%) at the follow-up visit (p = 0.003). Most referred women attended genetic counselling (22/29, 76%) and had BRCA genetic testing (21/22, 95%). Four BRCA1 mutations were detected (4/21, 19%).
Conclusions: Oncologists discuss genetic counselling with a minority of ovarian cancer patients. Mainstreaming such practice is important to optimize the management of these patients and their families. Efforts are needed to identify new models for introducing ovarian cancer genetic risk assessment in oncology practice.
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| http://dx.doi.org/10.1159/000431352 | DOI Listing |
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