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Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets.
Cancers (Basel)
December 2024
SydPath, St Vincent's Hospital Sydney, Darlinghurst, NSW 2010, Australia.
: Uveal melanomas (UMs) are rare but often deadly malignancies that urgently require viable treatment options. UMs often exhibit tumour heterogeneity, with macroscopic and microscopic differences in morphology between different regions of the same tumour. However, to date, the clinical significance of this and how it may help guide personalised therapy have not been realised.
View Article and Find Full Text PDFUveal metastasis: clinical characteristics, treatment, and prognostic factors in a cohort of 161 patients in China.
Can J Ophthalmol
January 2025
Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology &Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Objective: To investigate the clinical and prognostic features of uveal metastasis in a Chinese population and compare these features across different primary cancers.
Design: Retrospective cross-sectional study.
Participants: 161 patients with uveal metastasis at Beijing Tongren Hospital.
Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.
Front Immunol
January 2025
Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.
Methods: In this study, we used imaging mass cytometry (IMC) to assess the spatial heterogeneity of MIBC microenvironment across 185 regions of interest in 40 tissue samples.
Single-cell RNA sequencing reveals key molecular drivers and immune landscape in uveal melanoma: implications for targeted therapy and prognostic modeling.
Front Immunol
December 2024
Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Background: Uveal melanoma (UM), arising from melanocytes in the choroid, accounts for 3% to 5% of all melanocytic tumors and over 70% of intraocular malignancies. Despite effective local treatments, metastasis remains a significant challenge, with more than half of patients developing metastatic disease within ten years. Conventional therapies often yield poor outcomes, highlighting the urgent need for novel therapeutic strategies to enhance survival and prognosis for UM patients.
View Article and Find Full Text PDFEarly Salience Signals Predict Interindividual Asymmetry in Decision Accuracy Across Rewarding and Punishing Contexts.
Hum Brain Mapp
December 2024
University of Glasgow, Glasgow, Scotland.
Asymmetry in choice patterns across rewarding and punishing contexts has long been observed in behavioural economics. Within existing theories of reinforcement learning, the mechanistic account of these behavioural differences is still debated. We propose that motivational salience-the degree of bottom-up attention attracted by a stimulus with relation to motivational goals-offers a potential mechanism to modulate stimulus value updating and decision policy.
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