Antimicrobials are routinely used in the treatment of chronic and problematic wounds. Despite the on-going increase in numbers and types of products, well-designed clinical trials that support their efficacy are limited. Antimicrobial products are applied with understanding of their mechanisms of action and role in wound repair. This manuscript reviews the major categories of products on the market, providing the clinician with information on the different types of products and their purported effect on wounds. A new product containing polyhexamethylene biguanide is described in greater detail with relevant case presentations and cost data. This new product does not appear to have any known cytotoxicity in the dressing configuration and may be applied to a wide range of wounds.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Activity of Antiseptics Against and Its Adaptation Potential.
Antibiotics (Basel)
January 2025
Department of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznań, Poland.
Background/objectives: rapidly acquires antibiotic resistance and demonstrates increasing tolerance to antiseptics. This study evaluated the activity of eight antiseptics against , assessed its ability to develop adaptation to these antiseptics, and, for the first time, determined the Karpinski Adaptation Index (KAI) for this bacterium.
Methods: The minimal inhibitory concentration (MIC), susceptibility to antibiotics, bactericidal time according to EN 1040:2005, adaptation potential, and KAI of strains were evaluated.
Comparative evaluation of chlorhexidine gluconate with alcohol and polyhexamethylene biguanide with Tris-EDTA as antiseptic solutions for pre-operative skin preparation in dogs.
Vet World
November 2024
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Background And Aim: Skin antisepsis plays a crucial role in pre-operative skin preparation, with chlorhexidine gluconate and alcohol being historically the preferred choice. However, concerns have risen regarding the development of bacterial resistance to chlorhexidine. Polyhexamethylene biguanide (PHMB) combined with Tris-ethylenediaminetetraacetic acid (Tris-EDTA) has recently emerged as a skin and wound antiseptic.
View Article and Find Full Text PDFMXene/Ag-Based Zwitterionic Double-Network Hydrogels with Enhanced Mechanical Strength and Antifouling Performances.
ACS Appl Mater Interfaces
January 2025
School of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Biological fouling seriously jeopardizes the development of the marine industry. Although hydrogels, as a kind of state-of-the-art antifouling material, have received wide attention, their mechanical strength is still relatively weak, and the synergistic antifouling method is comparatively single, thus limiting the performance of hydrogels. Here, a zwitterionic sulfobetaine methacrylate (SBMA)-acrylamide (AM)/sodium alginate (SA) double-network (DN) antifouling hydrogel with superb antifouling ability and outstanding mechanical properties was prepared by grafting MXene/Ag (M/Ag) and the powerful biocide polyhexamethylene biguanide (PHMB).
View Article and Find Full Text PDFThe use of topical antiseptic solutions in the healing process of post-surgical skin wounds in dogs (Canis lupus familiaris).
Acta Cir Bras
January 2025
Universidade Federal Rural de Pernambuco - Programa de Pós-Graduação em Medicina Veterinária - Departamento de Morfologia e Fisiologia Animal - Recife (PE) - Brazil.
Purpose: To evaluate whether the effectiveness of topical antiseptic solutions in restoring skin continuity solutions is related to their antimicrobial action or to their action in maintaining moisture, in dogs undergoing elective surgeries.
Methods: Forty dogs, 20 males and 20 females, underwent orchiectomy and oophorectomy, respectively. Thereafter, the animals were allocated into four groups (n = 5) and treated with different topical solutions: polyhexanide 0.
Experiments and modelling of pulmonary surfactant disruption by aerosolised compounds.
Colloids Surf B Biointerfaces
April 2025
The National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen DK-2100, Denmark. Electronic address:
Within the deep lung, pulmonary surfactant coats the air-liquid interface at the surface of the alveoli. This complex mixture of amphiphilic molecules and proteins modifies the surface tension and mechanical properties of this interface to assist with breathing. In this study, we examine the effects on pulmonary surfactant function by two industrially used compounds composing surfactants and polymers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!