AI Article Synopsis
- The study evaluated the clinical outcomes of 37 patients with brain arteriovenous malformations (AVM) who underwent single-dose reirradiation using LINAC, analyzing various patient and treatment characteristics.
- Results showed that 55.5% of patients had angiographic occlusion post-treatment, and a significant predictor of AVM cure was a reduction in nidus volume over 50% from the first procedure.
- The findings suggest that single-dose reirradiation is safe for partially occluded AVM, but it may be ineffective if the initial dose was below 15.5 Gy or if the nidus volume reduction was less than 50% prior to reirradiation.
Article Abstract
Background: The aim of this study was to evaluate the clinical outcome of patients undergoing single-dose reirradiation using the Linear Accelerator (LINAC) for brain arteriovenous malformations (AVM).
Methods: A retrospective study of 37 patients with brain AVM undergoing LINAC reirradiation between April 2003 and November 2011 was carried out. Patient characteristics, for example, gender, age, use of medications, and comorbidities; disease characteristics, for example, Spetzler-Martin grading system, location, volume, modified Pollock-Flickinger score; and treatment characteristics, for example, embolization, prescription dose, radiation dose-volume curves, and conformity index were analyzed. During the follow-up period, imaging studies were performed to evaluate changes after treatment and AVM cure. Complications, such as edema, rupture of the blood-brain barrier, and radionecrosis were classified as symptomatic and asymptomatic.
Results: Twenty-seven patients underwent angiogram after reirradiation and the percentage of angiographic occlusion was 55.5%. In three patients without obliteration, AVM shrinkage made it possible to perform surgical resection with a 2/3 cure rate. A reduction in AVM nidus volume greater than 50% after the first procedure was shown to be the most important predictor of obliteration. Another factor associated with AVM cure was a prescription dose higher than 15.5 Gy in the first radiosurgery. Two patients had permanent neurologic deficits. Factors correlated with complications were the prescription dose and maximum dose in the first procedure.
Conclusion: This study suggests that single-dose reirradiation is safe and feasible in partially occluded AVM. Reirradiation may not benefit candidates whose prescribed dose was lower than 15.5 Gy in the first procedure and initial AVM nidus volume did not decrease by more than 50% before reirradiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462616 | PMC |
| http://dx.doi.org/10.4103/2152-7806.158205 | DOI Listing |
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