Thyroid hormones (THs) are essential for normal development of the mammalian central nervous system through regulation of TH-responsive genes. EphA5, an important TH-responsive gene encoding the tyrosine kinase receptor EphA5, regulates synaptogenesis initiation and synaptic remodeling during brain development. Abnormal EphA5 expression is involved in the development of congenital hypothyroidism (CH). To show the regulatory mechanism of EphA5 expression in CH rats, we analyzed the correlation between methylation of the EphA5 promoter and its expression in the hypothyroid hippocampus and hippocampal neurons. Demethylation treatment using 5'-azadeoxycytidine upregulated EphA5 expression and rescued the effects of hypermethylation, suggesting a novel regulatory mechanism of EphA5 expression in CH rats. Our results suggest a potentially new approach for the development of drugs to restore neurocognitive impairments associated with CH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12031-015-0603-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole genome and transcriptome analyses in dairy goats identify genetic markers associated with high milk yield.
Int J Biol Macromol
December 2024
Shaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China. Electronic address:
Milk production is the most important economic trait of dairy goats and a key indicator for genetic improvement and breeding. However, milk yield is a complex phenotypic trait, and its genetic mechanisms are still not fully understood. This study focuses on dairy goats and non-dairy goats.
View Article and Find Full Text PDFImmunohistochemical expression of ephrin receptors in neuroendocrine neoplasms: a case-series of gastroenteropancreatic neuroendocrine neoplasms and a systematic review of the literature.
Endocrine
October 2024
Endocrine Unit, First Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Article Synopsis
- The study investigates the expression of Erythropoietin-producing hepatocellular (EPH) receptors in neuroendocrine neoplasms (NENs), which are significant in various biological processes including tumor growth and spread.
- Immunohistochemical analysis of tumor samples from 30 patients showed varying levels of expression for different EPH subtypes, with high positivity rates for EPH-A4 and EPH-A5.
- The findings suggest that EPH receptors could play a crucial role in the development and treatment of NENs, highlighting their potential as targets for new therapeutic strategies.
[Clinicopathological analysis of gastric adenocarcinoma with elevated serum alpha-fetoprotein and enteroblastic differentiation].
Zhonghua Zhong Liu Za Zhi
July 2024
Department of Pathology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China.
To investigate the immunophenotypic and molecular biological characteristics of patients with elevated serum alpha-fetoprotein (AFP) and enteroblastic differentiated gastric adenocarcinoma (GAED). The clinicopathological data of 13 patients with elevated serum AFP and GAED admitted to Shanxi Cancer Hospital from 2018 to 2020 were collected. Immunohistochemistry (IHC) and next-generation sequencing (NGS) were used to analyze the immune markers and molecular biological characteristics of the pathological tissues of the patients.
View Article and Find Full Text PDFA pan-cancer analysis of EphA family gene expression and its association with prognosis, tumor microenvironment, and therapeutic targets.
Front Oncol
June 2024
Department of Pathology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Background: Erythropoietin-producing human hepatocellular (Eph) receptors stand out as the most expansive group of receptor tyrosine kinases (RTKs). Accumulating evidence suggests that within this expansive family, the EphA subset is implicated in driving cancer cell progression, proliferation, invasion, and metastasis, making it a promising target for anticancer treatment. Nonetheless, the extent of EphA family involvement across diverse cancers, along with its intricate interplay with immunity and the tumor microenvironment (TME), remains to be fully illuminated.
View Article and Find Full Text PDFmRNA-lncRNA gene expression signature in HPV-associated neoplasia and cervical cancer.
Vavilovskii Zhurnal Genet Selektsii
June 2024
Southern Federal University, Rostov-on-Don, Russia.
Cervical cancer is one of the most frequent cancers in women and is associated with human papillomavirus (HPV) in 70 % of cases. Cervical cancer occurs because of progression of low-differentiated cervical intraepithelial neoplasia through grade 2 and 3 lesions. Along with the protein-coding genes, long noncoding RNAs (lncRNAs) play an important role in the development of malignant cell transformation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!