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| http://dx.doi.org/10.1136/emj.6.4.288-a | DOI Listing |
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Background: This study investigates the impact of IGC-AD1, a combination comprising of low concentration of delta-9 tetrahydrocannabinol ("THC") and melatonin on blood serum potassium levels in patients with Alzheimer's disease ("AD"). Loss of intracellular compartmentalization of potassium is a characteristic of AD pathology, with supporting studies indicating significantly lower potassium levels in intracellular compartments of AD brains and an associated increase in serum potassium levels in AD subjects. Here, we present preliminary safety lab data from a Phase I trial of AD patients administered with IGC-AD1.
View Article and Find Full Text PDFExploring the association between familial hemiplegic migraine genes (, and ) with migraine and epilepsy: A UK Biobank exome-wide association study.
Cephalalgia
January 2025
Department of Biomedicine, Health Aarhus University, Aarhus, Denmark.
Background: Familial hemiplegic migraine (FHM) types 1-3 are associated with protein-altering genetic variants in , and , respectively. These genes have also been linked to epilepsy. Previous studies primarily focused on phenotypes, examining genetic variants in individuals with characteristic FHM symptoms.
View Article and Find Full Text PDFAn experiment was conducted for 60 days in a 500L capacity FRP tank containing inland ground saline water (fortified to a level of 50% potassium) with one control (sediment) and three treatments; T1(Paddy Straw Biochar (PSB) in sediment), T2 (Banana Peduncle Biochar (BPB) in sediment), and T3 (PSB + BPB in sediment). Biochar (100 g) was amended with sediment (25 kg) at 9 tons/ha. Shrimps of average weight 5 ± 0.
View Article and Find Full Text PDFDiuretic Potentiation Strategies in Acute Heart Failure.
JACC Heart Fail
January 2025
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA; Baylor Scott and White Research Institute, Baylor Scott and White Health, Dallas, Texas, USA. Electronic address:
Several trials have evaluated diuretic-based strategies to improve symptoms and outcomes in patients with acute heart failure (AHF). The authors sought to summarize the effect of different combination strategies on symptoms, physical signs, physiological variables, and outcomes in patients with AHF. Twelve trials were identified that assessed the addition of thiazide diuretics, sodium-glucose cotransporter 2 inhibitors, mineralocorticoid receptor antagonists, vasopressin receptor antagonists, carbonic anhydrase inhibitors, or loop diuretic intensification to conventional therapy for AHF.
View Article and Find Full Text PDFSevere Life-Threatening Hypokalemia Primarily Presented With Isolated Paralysis: Case Series From Ethiopia.
Clin Case Rep
January 2025
Nephrology Unit, Department of Internal Medicine, School of Health Sciences Addis Ababa University Addis Ababa Ethiopia.
Severe hypokalemia can primarily present as a weakness of the limbs, without any other clinical manifestation. A life-threatening level of decreased serum potassium level can be unusually present with isolated weakness of the limbs and might be misdiagnosed, or the diagnosis may be delayed.
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