A one-pot domino C-H, C-C activation in coumarins: a fast track to 2,3-diaryl benzo[b]furans.

Chem Commun (Camb)

Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, 14176, Tehran, Iran.

Published: July 2015

An approach to synthesize 2,3-diaryl benzo[b]furans using coumarins and aryl bromides is developed. This state-of-the-art strategy capitalizes on a palladium-catalyzed one-pot decarbonylative diarylation of coumarins, paving the way to achieve biologically interesting 2,3-diaryl benzo[b]furans.

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Source
http://dx.doi.org/10.1039/c5cc01427aDOI Listing

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