Introduction: Studies indicate that uric acid is involved in the development of hypertensive diseases of pregnancy, and that uric acid might influence the remodeling of the spiral arteries.
Objective: To investigate the relationship with uric acid and utero-placental hemodynamics in the second half of pregnancy.
Methods: 53 women with uncomplicated pregnancies were examined longitudinally at 4-weekly intervals from 22 to 40 weeks of gestation. Blood samples for plasma uric acid were analyzed (enzymatic colorimetric method.
Instrument: Modular P, Roche Diagnostic), and blood pressure (BP) was measured. Uterine artery Doppler velocity waveforms were obtained, and vessel diameter was measured bilaterally. Uterine artery volume blood flow (Quta) was calculated as the product of mean velocity and cross-sectional area of the vessel. Mean arterial pressure (MAP) was calculated as: diastolic BP+(systolic BP - diastolic BP)/3. Uterine artery resistance (Rquta) was calculated as: MAP/Quta. Uterine artery pulsatility index (UtaPI) was calculated as: (peak systolic velocity - end-diastolic velocity)/time-averaged maximum velocity. Linear mixed models and linear regression models were used for statistical analysis.
Results: 242 blood samples were analyzed. Uric acid increased from 176 to 238μmol/L. Rquta and UtaPI decreased from 0.26 to 0.13mmHg/ml/min and 0.8-0.6 respectively. Uric acid was significantly correlated to Rquta (p=0.005), but not to Uta PI (p=0.178).
Conclusion: There is a strong association between uric acid and uterine artery vascular resistance during the second half of pregnancy indicating that uric acid might play a role in establishing low resistance blood flow in the uteroplacental compartment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.preghy.2013.04.082 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Association Between Periodontal Inflamed Surface Area (PISA), Inflammatory Biomarkers, and Mitochondrial DNA Copy Number.
J Clin Med
December 2024
Department of Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana, Hrvatski trg 6, 1000 Ljubljana, Slovenia.
: Periodontitis is an inflammatory disease induced by bacteria in dental plaque that can activate the host's immune-inflammatory response and invade the bloodstream. We hypothesized that a higher periodontal inflamed surface area (PISA) is associated with higher levels of inflammatory biomarkers, lower levels of antioxidants, and mitochondrial DNA copy number (mtDNAcn). : Using periodontal parameters, we calculated the PISA score, measured the levels of inflammatory biomarkers and antioxidants in the serum, and took buccal swabs for mtDNA and nuclear DNA (nDNA) extraction.
View Article and Find Full Text PDFImpact of Uric Acid Levels on Mortality and Cardiovascular Outcomes in Relation to Kidney Function.
J Clin Med
December 2024
Department of Internal Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea.
: Uric acid levels are linked to cardiovascular outcomes and mortality, especially in chronic kidney disease (CKD). However, their impact across varying kidney function remains unclear. : We conducted a retrospective cohort study using the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) database from a single center.
View Article and Find Full Text PDFHigh-Intensity Interval Training Reduces Liver Enzyme Levels and Improves MASLD-Related Biomarkers in Overweight/Obese Girls.
Nutrients
January 2025
Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland.
Background/objectives: Despite the abundant body of evidence linking high-intensity interval training (HIIT) to cardiometabolic markers, little is known about how HIIT affects liver enzymes, particularly in obese adolescents. This study aimed to investigate the effects of HIIT on metabolic dysfunction-associated steatotic liver disease (MASLD)-related biomarkers in overweight/obese adolescent girls.
Methods: Thirty-three overweight/obese adolescent girls (age, 17.
Therapeutic Potential of Ketogenic Interventions for Autosomal-Dominant Polycystic Kidney Disease: A Systematic Review.
Nutrients
December 2024
Centre for Diabetes, Obesity and Endocrinology Research (CDOER), Westmead Institute for Medical Research, Westmead, Sydney, NSW 2145, Australia.
Background: Recent findings have highlighted that abnormal energy metabolism is a key feature of autosomal-dominant polycystic kidney disease (ADPKD). Emerging evidence suggests that nutritional ketosis could offer therapeutic benefits, including potentially slowing or even reversing disease progression. This systematic review aims to synthesise the literature on ketogenic interventions to evaluate the impact in ADPKD.
View Article and Find Full Text PDFThe Potential Mechanism of Fructus Against Hyperuricemia: An Integration of Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments.
Nutrients
December 2024
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
: Fructus (AOF) is a medicinal and edible resource that holds potential to ameliorate hyperuricemia (HUA), yet its mechanism of action warrants further investigation. : We performed network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments to investigate the potential action and mechanism of AOF against HUA. : The results indicate that 48 potential anti-HUA targets for 4 components derived from AOF were excavated and predicted through public databases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!