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A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations.
Int J Radiat Oncol Biol Phys
January 2024
Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- - A review of literature assessed various treatments for radiation necrosis (RN) resistant to corticosteroids, focusing on the effectiveness and safety of treatments like bevacizumab, laser interstitial thermal therapy (LITT), surgical resection, and hyperbaric oxygen therapy.
- - Bevacizumab showed promising results with an 86% improvement/stability rate for symptoms and very high rates for T2 (93%) and T1 postcontrast (94%) imaging outcomes; lower doses were particularly effective for symptom relief.
- - Other treatments such as LITT and surgical resection had similar efficacy, reporting 88% and 89% improvement/stability rates respectively, with toxicity generally reported as low across all treatment options. *
Calculating Utilities From the Spine Oncology Study Group Outcomes Questionnaire: A Necessity for Economic and Decision Analysis.
Spine (Phila Pa 1976)
September 2021
Division of Spine, Surgery Vancouver Spine Surgery Institute, Vancouver General Hospital University of British Columbia, Vancouver, Canada.
Study Design: General population utility valuation study.
Objective: The aim of this study was to develop a technique for calculating utilities from the Spine Oncology Study Group Outcomes Questionnaire v2.0 (SOSGOQ2.
In Regard to Susko et al.
Int J Radiat Oncol Biol Phys
March 2020
Department of Radiation Oncology, Sunnybrook Odette Cancer Center, University of Toronto, Toronto, ON, Canada.
Metastatic Spine Disease: Should Patients With Short Life Expectancy Be Denied Surgical Care? An International Retrospective Cohort Study.
Neurosurgery
August 2020
Division of Spine Surgery, Department of Orthopaedics, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.
Background: Despite our inability to accurately predict survival in many cancer patients, a life expectancy of at least 3 mo is historically necessary to be considered for surgical treatment of spinal metastases.
Objective: To compare health-related quality of life (HRQOL) in patients surviving <3 mo after surgical treatment to patients surviving >3 mo to assess the validity of this inclusion criteria.
Methods: Patients who underwent surgery for spinal metastases between August 2013 and May 2017 were retrospectively identified from an international cohort study.
Management of patients with brain metastases from non-small cell lung cancer and adverse prognostic features: multi-national radiation treatment recommendations are heterogeneous.
Radiat Oncol
February 2019
Department of Radiation Oncology, Miami Cancer Institute, Miami, FL, USA.
Background: Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over the last decade. It is not trivial to find the optimal balance of over- versus undertreatment in these patients. Several recent trials, including the randomized QUARTZ trial now influence the decision to recommend or withhold WBRT for patients with unfavorable prognosis, and similarly, for favorable prognosis patients, the balance between radiosurgery alone or WBRT has become a nuanced decision.
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