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Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia. | LitMetric

Effect of Serenoa Repens on Oxidative Stress, Inflammatory and Growth Factors in Obese Wistar Rats with Benign Prostatic Hyperplasia.

Phytother Res

Departamento Farmacobiología, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.

Published: October 2015

AI Article Synopsis

  • Serenoa repens, commonly used for treating benign prostatic hyperplasia, was specifically studied for its effects on obese rats with testosterone-induced prostatic hyperplasia.
  • The study measured various indicators of oxidative stress, inflammation, and growth factors, finding that the obese rats had greater prostate weights compared to controls.
  • Results showed that S. repens significantly reduced prostate weight and harmful markers while improving antioxidant activity and lowering inflammation, indicating its potential benefits for treating benign prostatic hyperplasia in obese individuals.

Article Abstract

Serenoa repens has been widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms; however, most of the studies have been conducted in individuals with normal weight and not obese. In this study, the effects of a lipidic extract of S. repens, in markers of oxidative stress, inflammation, and growth factors, in obese rats with testosterone-induced prostatic hyperplasia, were investigated. Total nitrites, malondialdehyde, total glutathione, superoxide dismutase (SOD), and catalase activity were measured; in addition, assays for inflammatory cytokines TNF-α, IL-1β, IL-6 and the growth factors basic fibroblast growth factor (FGFb) and vascular endothelial growth factor (VEGF) were performed. The obese rats had a higher prostate weight compared with controls. S. repens significantly decreased prostate weight, total nitrites, and malondialdehyde; improved total glutathione, SOD, and catalase activity; and significantly reduced inflammatory (TNF-α, IL-1β and IL-6) and growth factors (VEGF and FGFb). S. repens showed high antioxidant and antiinflammatory activity in obese rats, suggesting that their use could be beneficial in the treatment of benign prostatic hyperplasia.

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Source
http://dx.doi.org/10.1002/ptr.5406DOI Listing

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