The purpose of this study was to investigate the impact of a dose control system (DCS) servo installed on two fully commissioned TomoTherapy Hi·Art II treatment units. This servo is designed to actively adjust machine parameters to control the output variation of a tomotherapy unit to within ± 0.5% of the nominal dose rate. Machine output, dose rate, and patient-specific quality assurance data were retrospectively analyzed for periods prior to and following the installation of the servo system. Quality assurance tests indicate a reduction in the rotational variation of the output during a procedure, where the peak-to-peak amplitude of the variation was ± 1.30 prior to DCS and equal to ± 0.4 with DCS. Comparing two tomotherapy unit static outputs over four years the percentage error was 1.05% ± 0.7% and -0.4% ± 0.66% and, once DCS was installed, was reduced to -0.22% ± 0.29% and -0.08% ± 0.16%. The results of the quality assurance tests indicate that the dose control system reduced the output variation of each machine for both static and rotational delivery, leading to an improvement in the overall performance of the machine and providing greater certainty in treatment delivery.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690136PMC
http://dx.doi.org/10.1120/jacmp.v16i3.5489DOI Listing

Publication Analysis

Top Keywords

dose control
12
control system
12
quality assurance
12
tomotherapy hi·art
8
output variation
8
tomotherapy unit
8
dose rate
8
assurance tests
8
tests indicate
8
experiences dose
4

Similar Publications

Background: Although anthracycline-related cardiotoxicity is widely studied, only a limited number of echocardiographic studies have assessed cardiac function in breast cancer survivors (BCSs) beyond ten years from anthracycline treatment, and the knowledge of long-term cardiorespiratory fitness (CRF) in this population is scarce. This study aimed to compare CRF assessed as peak oxygen uptake (V̇O), cardiac morphology and function, and cardiovascular (CV) risk factors between long-term BCSs treated with anthracyclines and controls with no history of cancer.

Methods: The CAUSE (Cardiovascular Survivors Exercise) trial included 140 BCSs recruited through the Cancer Registry of Norway, who were diagnosed with breast cancer stage II to III between 2008 and 2012 and had received treatment with epirubicin, and 69 similarly aged activity level-matched controls.

View Article and Find Full Text PDF

Introduction: Optimising the micronutrient status of women before and during reproduction confers benefits to them and their offspring. Antenatal multiple micronutrient supplements (MMS), given as a daily tablet with nutrients at ~1 recommended dietary allowance (RDA) or adequate intake (AI) reduces adverse birth outcomes. However, at this dosage, MMS may not fully address micronutrient deficiencies in settings with chronically inadequate diets and infection.

View Article and Find Full Text PDF

A man in his 60s suffered from refractory, biopsy-proven subacute cutaneous lupus erythematosus that required chronic, moderate dose steroids to manage. His rash was accompanied by arthralgias and negative autoantibody testing. His subacute lupus erythematosus (SCLE) was responsive to tofacitinib, but thrombotic complications limited the use of this medication.

View Article and Find Full Text PDF

Background: To determine outcomes of MRI-assisted radiosurgery (MARS) for salvage brachytherapy using the radioisotope Pd after various upfront treatments including surgery, external beam radiotherapy, and brachytherapy.

Methods: We retrospectively reviewed data for patients who underwent salvage MARS for intraprostatic lesions or prostate bed recurrences from 2016 to 2022. Biochemical recurrence, prostate cancer-specific, and overall survival, and the cumulative incidences of toxicities, were determined by Kaplan-Meier estimates.

View Article and Find Full Text PDF

This study used Raman and near-infrared (NIR) spectroscopy to monitor small real-time changes in powder blends and tablets in low-dose pharmaceutical formulations. The research aims to enhance process analytical technology (PAT) in pharmaceutical manufacturing, ensuring high-quality and uniform products with applications to produce drugs with narrow therapeutic indices (NTI). The study utilizes Raman and NIR spatially resolved spectroscopy (SRS) techniques to monitor a moderate cohesive material's active pharmaceutical ingredient (API) concentrations during manufacturing.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!