AI Article Synopsis
- Small molecule drug discovery often focuses on new and uncharted areas of drug targets.
- Medicinal chemistry plays a crucial role by creating molecules that help yield trustworthy results in testing the target's effectiveness.
- The text emphasizes various aspects of chemistry that contribute to achieving the most reliable outcomes in these validation studies.
Article Abstract
Small molecule drug discovery commonly ventures into previously unknown and unexplored target space. For such programs, an important role of medicinal chemistry is to generate molecules that enable the most reliable conclusions from a preclinical target validation/invalidation study. Multiple facets of chemistry that provide the most rigorous results for such an experiment are highlighted.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468394 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.5b00183 | DOI Listing |
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