AI Article Synopsis
- The accessory limb model is a new experimental system used to study how amphibians regenerate limbs, contributing to our understanding of organ regeneration.
- This model has helped identify key molecules, like BMP7, FGF2, and FGF8, that can trigger limb regeneration processes in urodele amphibians.
- The findings from this research may have broader implications and could be applicable to other species, potentially revealing universal mechanisms of regeneration.
Article Abstract
Limb regeneration ability, which can be observed in amphibians, has been investigated as a representative phenomenon of organ regeneration. Recently, an alternative experimental system called the accessory limb model was developed to investigate early regulation of amphibian limb regeneration. The accessory limb model contributed to identification of limb regeneration inducers in urodele amphibians. Furthermore, the accessory limb model may be applied to other species to explore universality of regeneration mechanisms. This review aims to connect the insights recently gained to emboss universality of regeneration mechanisms among species. The defined molecules (BMP7 (or2) + FGF2 + FGF8) can transform skin wound healing to organ (limb) regeneration responses. The same molecules can initiate regeneration responses in some species.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/dgd.12230 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!