AI Article Synopsis
- The study investigates serum lactate as a potential biomarker for non-glial cell brain tumors, highlighting its role in rapidly growing tumors due to the Warburg effect.
- Recent findings indicate that patients with metastatic brain tumors show significantly higher serum lactate levels compared to those with meningioma and pituitary tumors, suggesting a strong link between lactate levels and tumor malignancy.
- The researchers emphasize the need for further studies with larger populations to validate serum lactate's effectiveness in monitoring therapy responses and early tumor recurrence.
Article Abstract
We assess whether serum lactate is a potential biomarker for non-glial cell brain tumors. Rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin and produce lactate even in the presence of oxygen. This phenomenon is called the Warburg effect. We recently showed that serum lactate levels can be used as a potential non-invasive biomarker in glial cell brain tumors, which correlates with both tumor grade and the extent of malignancy. In the present study, we found that patients with metastatic brain tumors had significantly higher baseline serum lactate levels compared to patients with meningioma and pituitary tumors. There was a statistically significant association between metastatic brain tumors and elevated serum lactate. We demonstrate that lactate can be used as a non-invasive biomarker to determine malignancy for brain tumors. Further analyses of larger populations will be needed to establish the value of serum lactate in determining the response to therapy or early recurrence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jocn.2015.05.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!