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Risk factors for steroid-induced osteonecrosis of the femoral head in children with immune kidney disease.
Clin Kidney J
March 2025
Orthopedics Department, Children's Hospital of Chongqing Medical University.
Objective: To investigate the risk factors for steroid-induced osteonecrosis of the femoral head (SONFH) after glucocorticoid (GC) therapy in children with immune kidney diseases.
Methods: This retrospective study included patients (1-18 years) diagnosed with immune kidney disease treated with GCs from January 2012 to July 2022 in our hospital. Data, such as sex, age and body weight at the first GC treatment, and the GC dose, were collected.
Incidence and Risk Factors for Steroid-associated Osteonecrosis in Children and Adolescents: A Systematic Review of the Literature.
J Pediatr Orthop
March 2025
Department of Orthopaedic Surgery, Stanford University, Redwood.
Objective: Steroid-associated osteonecrosis in pediatric patients with inflammatory and oncologic disease is an uncommon yet debilitating condition causing significant functional disability. Pediatric orthopaedic surgeons encounter this population during stages in which surgical intervention may be necessary for joint preservation. Various risk factors for steroid-associated osteonecrosis have been suggested, but a comprehensive systematic review of the literature has not been performed.
View Article and Find Full Text PDFFatty Degenerative Osteonecrosis of the Jaw: Bridging Molecular Insights and Clinical Practice-A Scoping Review.
Int J Mol Sci
February 2025
Department of Dental Surgery, Faculty of Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland.
Fatty degenerative osteonecrosis of the jaw (FDOJ) is a chronic, aseptic inflammatory condition that is characterized by molecular disruptions in bone metabolism and necrotic bone marrow within the jawbone cavities. In contrast to the overt clinical signs typically observed in osteopathies, FDOJ frequently presents with a "silent inflammation" phenotype. The electronic databases PubMed, Scopus, and Embase were searched using appropriate search terms, and the methodology was performed according to PRISMA-ScR guidelines.
View Article and Find Full Text PDFAging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
Int Immunopharmacol
March 2025
Department of Bone and Joint Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:
Background: Glucocorticoid (GC) overuse is the main cause of osteonecrosis of the femoral head (ONFH). The dysfunction of bone marrow mesenchymal stem cells (BMSCs) plays an important role in ONFH pathogenesis. Physiological concentrations of GCs can induce the osteogenic differentiation of BMSCs; however, intervention with high concentrations of GC may lead to changes in aging and autophagy in certain cell types.
View Article and Find Full Text PDFEvaluation of the effects of bisphosphonate therapy on the temporomandibular joint using cone beam computed tomography.
Oral Radiol
March 2025
Faculty of Dentistry, Departmant of Oral and Maxillofacial Radiology, Akdeniz University, Konyaaltı, 07058, Antalya, Turkey.
Objective: The aim of this study was to evaluate the mandibular condyle and articular eminences of patients diagnosed with medication-related osteonecrosis of the jawbone (MRONJ) and those who use bisphosphonates (BP) but do not have MRONJ findings, by comparing them with a healthy control group.
Methods: The cone beam computed tomography (CBCT) images of 20 patients (15 male, 5 female) who were diagnosed with MRONJ and 20 patients (16 male and 4 female) who were using bisphosphonates but had no MRONJ were included in the study. A control group consisted of 20 age- and gender-matched patients (13 male, 7 female) who had no clinical complaints or signs and symptoms of TMD or rheumatic disease.
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