AI Article Synopsis
- A new carbonylation method using Pd catalyst allows for the coupling of various halides, including aryl and vinyl types, with N-hydroxysuccinimidyl formate as a carbon monoxide substitute.
- High yields of up to 98% were achieved, demonstrating the effectiveness of this protocol.
- The Pd(OAc)2/Xantphos catalyst system proved to be essential for ensuring high conversion rates to the desired NHS esters.
Article Abstract
An efficient Pd-catalyzed carbonylation protocol is described for the coupling of a large panel of aryl, heteroaryl, benzyl, vinyl and allyl halides 2 with the unusual N-hydroxysuccinimidyl (NHS) formate 1 as a CO surrogate to afford the corresponding valuable NHS esters 3. High conversion to the coupling products was achieved with up to 98% yield by means of Pd(OAc)2/Xantphos catalyst system.
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| http://dx.doi.org/10.1021/acs.joc.5b01119 | DOI Listing |
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