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| http://dx.doi.org/10.1038/kisup.2015.1 | DOI Listing |
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A case for broadening our view of mechanism in developmental biology.
Development
January 2025
Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that molecular/genetic explanations achieved via perturbations of gene function are the primary means of advancing mechanistic knowledge. We believe this to be a limited perspective, one that does not effectively represent the breadth of work in our field.
View Article and Find Full Text PDFNon-canonical Roles of Complement in the CNS: From Synaptic Organizer to Presynaptic Modulator of Glutamate Transmission.
Curr Neuropharmacol
January 2025
Department of Pharmacy, DIFAR, Pharmacology and Toxicology Section, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy.
The central nervous system (CNS) is not an immune-privileged compartment, but it is intimately intertwined with the immune system. Among the components shared by the two compartments is the complement, a main constituent of innate immunity, which is also produced centrally and controls the development and organization of synaptic connections. Complement is considered a doubled-faced system that, besides controlling the physiological development of the central network, also subserves synaptic engulfment pivotal to the progression of neurodegenerative diseases.
View Article and Find Full Text PDFCan the prevalence of one STI serve as a predictor for another? A mathematical modeling analysis.
Infect Dis Model
June 2025
Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
We aimed to understand to what extent knowledge of the prevalence of one sexually transmitted infection (STI) can predict the prevalence of another STI, with application for men who have sex with men (MSM). An individual-based simulation model was used to study the concurrent transmission of HIV, HSV-2, chlamydia, gonorrhea, and syphilis in MSM sexual networks. Using the model outputs, 15 multiple linear regression models were conducted for each STI prevalence, treating the prevalence of each as the dependent variable and the prevalences of up to four other STIs as independent variables in various combinations.
View Article and Find Full Text PDFInvestigating the linkage between knowledge sharing attitude, self-efficacy, and behavior in Bangladeshi information technology sector: Knowledge sharing intention as a mediator.
Heliyon
January 2025
Department of Business Administration, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
The research aims to investigate how employees' knowledge-sharing behavior (KSB) is affected by knowledge-sharing attitude (KSA) and knowledge-sharing self-efficacy (KSSE) when knowledge-sharing intention (KSI) is a mediator at IT companies in Bangladesh, using the widely accepted Theory of Planned Behavior as the underlying research framework. This investigation is explanatory in nature which emphasizes on the link among variables and follows quantitative research method. Data was assembled in google form applying convenience sampling from 295 employees working in seven IT companies of Bangladesh.
View Article and Find Full Text PDFMapping the scarcity of data on antibiotics in natural and engineered water environments across India.
Front Antibiot
February 2024
School of Biosciences & Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Antimicrobial resistance is a growing public health concern, increasingly recognized as a silent pandemic across the globe. Therefore, it is important to monitor all factors that could contribute to the emergence, maintenance and spread of antimicrobial resistance. Environmental antibiotic pollution is thought to be one of the contributing factors.
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