Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus (TM) OCT, and the Spectral Domain (SD-OCT) Spectralis (TM) and Cirrus (TM) OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration.
Design: Prospective observational study.
Setting: University-based retina practice.
Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD.
Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices.
Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability.
Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis (TM) and similar and higher for Cirrus (TM) and Stratus (TM). Agreement, CORs, and ICCs generally improved after manual correction, but only minimally.
Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457115 | PMC |
| http://dx.doi.org/10.12688/f1000research.2-131.v2 | DOI Listing |
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