Construction of the 5,6,7-tricyclic skeleton of lancifodilactone F.

Tetrahedron Lett

Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, United States.

Published: June 2015

We report herein the synthesis of a fully functionalized B,C,D-ring system of lancifodilactone F. The key transformations involve an arene-olefin -photocycloaddition reaction and a palladium-catalyzed oxidative C-C cleavage reaction to establish its B,C-rings.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472376PMC
http://dx.doi.org/10.1016/j.tetlet.2014.12.054DOI Listing

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