The synthesis of a C(1)-C(24) advanced southern hemisphere fragment towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chemistry (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470430 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2014.12.026 | DOI Listing |
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