AI Article Synopsis
- A new method transforms salicylaldehydes into meta-arylated phenol derivatives using a series of chemical reactions (oxidation, arylation, and protodecarboxylation).
- This technique utilizes the aldehyde group as a temporary directing group, allowing for precise control over where C-H activation occurs.
- Aldehydes are simple to add to starting materials and can be easily removed after the functionalization process.
Article Abstract
A method that allows salicylaldehydes to be efficiently transformed into meta-arylated phenol derivatives through a cascade oxidation/arylation/protodecarboxylation sequence is presented. We demonstrate that the aldehyde functional group can be used as a convenient removable directing group to control site selectivity in C-H activation. Aldehydes are easily introduced into the starting materials and the group is readily cleaved after the C-H functionalization event.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744983 | PMC |
| http://dx.doi.org/10.1002/asia.201500506 | DOI Listing |
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Similar Publications
A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols.
Chem Asian J
February 2016
School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Article Synopsis
- A new method transforms salicylaldehydes into meta-arylated phenol derivatives using a series of chemical reactions (oxidation, arylation, and protodecarboxylation).
- This technique utilizes the aldehyde group as a temporary directing group, allowing for precise control over where C-H activation occurs.
- Aldehydes are simple to add to starting materials and can be easily removed after the functionalization process.
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