The total synthesis and structural revision of antibiotic CJ-16,264 is described. Starting with citronellal, the quest for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereoselectively the decalin system and included the synthesis of six isomers before demystification of its true structure.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530996 | PMC |
| http://dx.doi.org/10.1002/anie.201504337 | DOI Listing |
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