AI Article Synopsis
- - A meta-analysis was performed to examine the relationship between the LEPR Gln223Arg polymorphism and type 2 diabetes (T2DM).
- - The analysis included data from 16 studies, which collectively involved 7,827 participants.
- - Findings indicate that the LEPR Gln223Arg polymorphism does not significantly influence the risk of developing type 2 diabetes.
Article Abstract
A meta-analysis was conducted to evaluate the association of LEPR Gln223Arg polymorphism with type 2diabetes (T2DM). Sixteen individual studies with 7827 subjects were included into the meta-analysis. Current studies suggest that LEPR Gln223Arg polymorphism may not affect the susceptibility with type 2diabetes (T2DM).
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| http://dx.doi.org/10.1016/j.diabres.2015.05.042 | DOI Listing |
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Article Synopsis
- Type 2 diabetes mellitus (T2DM) is linked to high blood sugar due to reduced insulin activity, and a study from South India explored genetic factors, particularly the LEPR gene polymorphism rs1137101, in its development.* -
- Researchers analyzed data from 311 participants and conducted a meta-analysis involving 254 previous studies, assessing the quality of these studies and finding a significant association between the rs1137101 polymorphism and increased T2DM risk.* -
- The study employed various genetic models, indicating that specific genetic variations play a crucial role in the likelihood of developing T2DM, with findings supporting existing research in diverse populations.*
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