S-Nitrosothiols (SNO) and their biological implications as an important post-translational modification are under active investigation. In our work on bioorthogonal reactions of protein SNO we have uncovered chemistry of this functionality that shows synthetic promise. Herein we report a phosphine-mediated reaction between SNO and aldehydes to form thioimines. A simple synthesis of benzoisothiazole based on this reaction is presented.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467916 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2015.04.017 | DOI Listing |
Publication Analysis
Top Keywords
phosphine mediated
4
mediated conjugation
4
conjugation s-nitrosothiols
4
s-nitrosothiols aldehydes
4
aldehydes s-nitrosothiols
4
s-nitrosothiols sno
4
sno biological
4
biological implications
4
implications post-translational
4
post-translational modification
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!