AI Article Synopsis
- Perineurioma is a rare, benign skin tumor that arises from perineurial cells, with two main types identified: intraneural and extraneural, the latter including the sclerosing variant often found on acral skin.
- The study analyzed eight patients (five men and five women, ages 9-66) with sclerosing perineurioma, revealing distinctive microscopic features such as proliferation of specific cell types and distinct immunohistochemistry results.
- Highlighting these cases enhances awareness of sclerosing perineurioma among healthcare professionals, aiding in the differential diagnosis of skin lesions on acral areas.
Article Abstract
Introduction: Perineurioma is an infrequent and benign cutaneous neoplasm characterized by proliferation of perineurial cells. It is classified into two main types: intraneural and the extraneural or soft tissue perineurioma, in which the sclerosing variant is included. Sclerosing perineurioma is more frequently found on acral skin. Clinically, they are well-circumscribed,skin colored, nodular tumors.
Objective: Describe and communicate clinicopathologic findings from a case series of sclerosing acral perineurioma.
Material And Methods: This is a clinical, morphological and immunohistologic case study of eight patients with the diagnosis of sclerosing perineurioma.
Results: It included five men and five women, with ages ranging between nine and 66 years. All of them had lesion on acral skin. At microscopy study, the lesions showed a proliferation of epithelioid and spindle-shaped perineurial cells, arranged in small aggregates and short fascicles between thickened collagen bundles. Immunohistochemistry studies revealed that the proliferating cells expressed EMA, Claudin-1 and Glut-1, and were negative for S-100 protein.
Conclusions: It is important to report these infrequent skin tumors, so they can be taken into account in the differential diagnoses of acral lesions.
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