AI Article Synopsis
- The text discusses how metal resistance in bacteria is often linked to metal pollution and the use of antimicrobial metals in healthcare and agriculture.
- It proposes that protozoan predation and macrophage killing might also drive the evolution of copper/zinc resistance genes in bacteria.
- The review also presents the "copper pathogenicity island" found in E. coli and Salmonella from Danish pigs that were fed copper and zinc, establishing a link between metal resistance and bacterial pathogenicity.
Article Abstract
The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs.
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| http://dx.doi.org/10.1007/s00253-015-6749-0 | DOI Listing |
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