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Plasma Cardiac Troponin-I Concentration in Normal Horses and in Horses with Cardiac Abnormalities.
Animals (Basel)
January 2025
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Urbana, IL 61802, USA.
Cardiac troponin-I (cTnI) is a highly sensitive and specific marker of myocardial injury detectable in plasma by immunoassay techniques. Inclusion criteria over a 3-year period required a diagnosis of cardiac disease accompanied by electrocardiographic (ECG) and cardiac ultrasound examinations (n = 23) in adult horses (≥2 years of age). A second group of normal adult ponies (n = 12) was studied as a reference group.
View Article and Find Full Text PDFAn electrochemiluminescence biosensor based on silver-cysteine nanorod as an emitter and AgNP-decorated FeMoO as a signal amplifier for sensitive detection of heart-type fatty acid binding protein.
Mikrochim Acta
December 2024
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China.
An electrochemiluminescence (ECL) immunosensor was developed for the highly sensitive and specific detection of heart-type fatty acid binding protein (H-FABP) and the rapid diagnosis of acute myocardial infarction (AMI). H-FABP is a biomarker that is highly specific to cardiac tissue and is associated with a range of cardiac diseases. Following myocardial injury, the rate of increase in H-FABP levels is greater than that observed for myoglobin and troponin.
View Article and Find Full Text PDFRare Clinical Manifestation of Vasculitis.
Diagnostics (Basel)
November 2024
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Article Synopsis
- ANCA-associated vasculitis is linked to a significantly higher risk of cardiovascular issues, with rare but serious coronary artery involvement.
- A 68-year-old woman with p-ANCA vasculitis and severe kidney disease presented with chest pain and low blood pressure, showing signs of coronary vasospasm rather than blockage during testing.
- Treatment with medications such as amlodipine and corticosteroids successfully resolved her symptoms, highlighting the immune-mediated nature of the vascular inflammation.
Quantitative and rapid lateral flow immunoassay for cardiac troponin I using dendritic mesoporous silica nanoparticles and gold nanoparticles.
Anal Methods
January 2025
Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, China.
Acute myocardial infarction (AMI) is considered to be one of the predominant causes of human death; therefore, a rapid and accurate diagnostic method for AMI is urgently required. In this work, a highly sensitive lateral flow immunoassay (LFIA) platform was designed and fabricated for the quantitative determination of cardiac troponin I (cTnI) using a scanner, a smartphone and a colloidal gold immunoassay analyzer. To overcome the limitation of low sensitivity of traditional colloidal gold-based LFIA, three-dimensionally assembled gold nanoparticles (AuNPs) within a dendritic mesoporous silica nanoparticle (DMSN) scaffold were fabricated as signal labels.
View Article and Find Full Text PDFLabel-Free Liquid Crystal Aptamer Sensors Based on Single-Stranded Nucleic Acid π-Structures for Detecting cTnI.
Langmuir
December 2024
School of Life Science and Technology, Changchun University of Science and Technology, Changchun 130022, PR China.
Article Synopsis
- Cardiac troponin I (cTnI) is a vital biomarker for diagnosing heart injury, especially useful for early detection of conditions like acute myocardial infarction.
- * A new label-free liquid crystal aptamer sensor utilizes nucleic acid hybridization to detect cTnI levels quantitatively, by measuring changes in optical images when cTnI is present.
- * The sensor can detect cTnI concentrations as low as 5.16 pg/mL, and exhibits a linear response to varying concentrations, making it a cost-effective and reliable method for testing cTnI in serum samples.
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