Difficult to control atopic dermatitis (AD) presents a therapeutic challenge and often requires combinations of topical and systemic treatment. Causes of severe AD are individual in each patient (e.g. genetic, barrier function, allergies). In this review, we will examine the highly complex interplay among skin barrier abnormality, allergy, immune dysregulation and antimicrobial peptide as a trinity in the development of AD. Studying of pathogenesis of formation of the complicated current the AD is a key problem of successful control as contamination of skin, and allergic inflammation.
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