Objectives: Double-duct sign (combined dilatation of the common bile duct and pancreatic duct) is an infrequently encountered finding in cross-sectional radiological imaging of the pancreatobiliary system. This sign is commonly deemed to signify on ominous pathology and suggests the presence of pancreatic or biliary malignancy.
Methods: We aim to correlate double-duct sign discovered on magnetic resonance cholangiopancreatogram (MRCP) in the clinical context. We retrospectively analyzed MRCP database over a period of 4 years, January 2010 to December 2013. Follow-up information was available for a median of 27 months (range, 12-42 months)
Results: The commonest cause of double-duct sign was choledocholithiasis followed closely by pancreatobiliary malignancy. Patients with jaundice in the context of double-duct sign had a higher incidence of malignancy (48%). None of the anicteric patients were found to have malignancy (P = 0.002).
Conclusions: In patients with MRCP evidence of double-duct sign, the absence of jaundice makes a malignant etiology unlikely. Conversely, in jaundiced patients, a malignant cause is much more likely. Figures from larger series are needed to support this conclusion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/MPA.0000000000000372 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rare Presentation of Leiomyoma of the Pancreas.
Ochsner J
January 2024
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Article Synopsis
- Leiomyomas are rare benign tumors from smooth muscle cells, with pancreatic cases being extremely uncommon, with only 6 known instances before this one.
- A 21-year-old male presented with unusual symptoms, including jaundice and anemia, leading to the discovery of a mass in the pancreas through advanced imaging techniques.
- The diagnosis of a low-grade leiomyoma was confirmed through biopsy and surgical removal, underscoring the need to consider such tumors in young patients and advocating for surgical resection as the best treatment option.
Lemmel Syndrome: Unveiling the Underrecognized Pancreatobiliary Diagnosis, Management Strategies, and Future Directions.
Cureus
June 2024
Department of Gastroenterology, Albert Einstein College of Medicine, Jacobi Medical Center, New York City, USA.
Lemmel syndrome, a rare condition, is characterized by biliary obstruction caused by a periampullary diverticulum (a pouch-like outgrowth of the duodenum near the ampulla of Vater). In our case, a 76-year-old male patient presented with epigastric pain and exhibited a cholestatic pattern on liver function tests. Imaging revealed dilated pancreatic and common bile ducts due to compression by a periampullary diverticulum (double duct sign: simultaneous dilation of the common bile duct and pancreatic duct).
View Article and Find Full Text PDFMalignancy and mass-forming phenotypes of IgG4-related disease: a challenging diagnosis.
BMJ Case Rep
July 2024
Gastroenterology, Hospital Beatriz Angelo, Loures, Lisboa, Portugal
Mass-forming phenotypes of IgG4-related disease (IgG4-RD) mimic malignancy and histological confirmation can be challenging. A woman in her 70s with HIV infection presented with painless obstructive jaundice and weight loss. Magnetic resonance imaging was suggestive of unresectable cholangiocarcinoma.
View Article and Find Full Text PDFSerous cystic neoplasm of pancreas with surgical obstructive jaundice and double duct sign: Cystadenoma or cystadenocarcinoma?
Indian J Gastroenterol
April 2024
Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
Clinical Significance and Resource Burden of Double Duct Sign in Non-jaundiced Patients.
Cureus
March 2024
Department of Hepatopancreatobiliary (HPB) Surgery, University Hospitals of Leicester NHS Trust, Leicester, GBR.
Aim The study aims to determine the incidence of malignancy at presentation and subsequent risk of malignancy (at 12 months follow-up) in a cohort of patients with double duct sign (DDS) on cross-sectional imaging but no visible stigmata of jaundice. The study also correlates malignancy with liver enzyme dysfunction and estimates the resource burden incurred during the investigation of these patients. Methods A search for the key term "double duct sign" was undertaken in the radiological database of a tertiary hepatopancreatobiliary (HPB) centre between March 2017 and March 2022.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!