Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/522274a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An empirical study of LLaMA3 quantization: from LLMs to MLLMs.
Vis Intell
December 2024
Department of Information Technology and Electrical Engineering, ETH Zurich, Sternwartstrasse 7, Zürich, Switzerland.
The LLaMA family, a collection of foundation language models ranging from 7B to 65B parameters, has become one of the most powerful open-source large language models (LLMs) and the popular LLM backbone of multi-modal large language models (MLLMs), widely used in computer vision and natural language understanding tasks. In particular, LLaMA3 models have recently been released and have achieved impressive performance in various domains with super-large scale pre-training on over 15T tokens of data. Given the wide application of low-bit quantization for LLMs in resource-constrained scenarios, we explore LLaMA3's capabilities when quantized to low bit-width.
View Article and Find Full Text PDFSingle-molecule localisation microscopy (SMLM) is feasible in human and animal formalin fixed paraffin embedded (FFPE) tissues in medical renal disease.
J Clin Pathol
January 2025
Pathology & Data Analytics, Leeds Institute of Medical Research at St. James's, School of Medicine, University of Leeds, Leeds, LS9 7TF, UK.
Aims: Establishment of a protocol for routine single-molecule localisation microscopy (SMLM) imaging on formalin fixed paraffin embedded (FFPE) tissue using medical renal disease including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS).
Methods: Protocol for normal and diseased renal FFPE tissue was developed to investigate the clinical diagnostic potential of SMLM. Antibody concentrations were determined for confocal microscopy and transferred to SMLM.
Nanosized core-shell bio-hybrid microgels and their internal structure.
Nanoscale
January 2025
Institute of Physical Chemistry, RWTH Aachen University, Landoltweg 2, 52074 Aachen, Germany.
Microgels are versatile materials with applications across biomedicine, materials science, and beyond. Their controllable size and composition enables tailoring specific properties, yet characterizing their internal structures on the nanoscale remains challenging. Super-resolution fluorescence microscopy (SRFM) effectively analyzes sub-μm structures, including microgels, offering a tool for investigating more complex systems such as core-shell microgels.
View Article and Find Full Text PDFUsing HBmito Crimson to Observe Mitochondrial Cristae Through STED Microscopy.
Bio Protoc
January 2025
Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Material Science, Hebei University. Baoding, China.
Mitochondrial cristae, formed by folding the mitochondrial inner membrane (IM), are essential for cellular energy supply. However, the observation of the IM is challenging due to the limitations in spatiotemporal resolution offered by conventional microscopy and the absence of suitable in vitro probes specifically targeting the IM. Here, we describe a detailed imaging protocol for the mitochondrial inner membrane using the Si-rhodamine dye HBmito Crimson, which has excellent photophysical properties, to label live cells for imaging via stimulated emission depletion (STED) microscopy.
View Article and Find Full Text PDFClinical Outcomes in Patients Undergoing Sequential Intragastric Balloon (IGB) Treatment for Super Obesity: A Single Centre Retrospective Analysis.
J Metab Bariatr Surg
December 2024
Department of General Surgery, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, Yorkshire, United Kingdom.
Purpose: We aimed to assess outcomes in patients undergoing sequential intragastric balloon (IGB) treatment for obesity.
Materials And Methods: Consecutive patients who underwent treatment between May 2014 and February 2023 were identified. We recorded outcomes including: weight at 3-monthly intervals, progression to definitive bariatric procedure and morbidity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!