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Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications.
Drug Des Devel Ther
January 2025
Department of Stomatology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing, 100091, People's Republic of China.
Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement in orthodontics, periodontitis, oral squamous cell carcinoma (OSCC), and hand, foot, and mouth disease (HFMD). Exosomes have a positive effect on the inflammatory environment of the oral cavity, remodeling and regeneration of oral tissues, and offer promising therapeutic options for bone and periodontal tissue restoration.
View Article and Find Full Text PDFAccuracy of Digital Intraoral Scans Three-dimensional Surface Analysis Compared with Plaster Models Dental Measurement in Mixed Dentition.
Int J Clin Pediatr Dent
December 2024
Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Aims And Background: This study aimed to assess the accuracy of digital intraoral scans in capturing the three-dimensional (3D) surface of teeth and dental arches in mixed dentition, compared with conventional plaster models. Intraoral scanning technology has seen rapid advancements in recent years, revolutionizing orthodontic and dental practices. However, its accuracy in mixed dentition remains a subject of investigation.
View Article and Find Full Text PDFVertical Mandibular Asymmetry in Unilateral Cleft Lip and Palate: A Comparative Analysis With Skeletal Class III and Class I Malocclusions.
Cureus
December 2024
Department of Orthodontics and Dentofacial Orthopedics, Government Dental College, Thiruvananthapuram, Thiruvananthapuram, IND.
Introduction Unilateral cleft lip and palate (UCLP) often leads to maxillary hypoplasia and skeletal Class III malocclusion, with conflicting evidence on mandibular asymmetry. This study evaluated vertical mandibular asymmetry in UCLP patients, comparing them with non-cleft individuals having skeletal Class III and Class I malocclusions. Methods Mandibular asymmetry was evaluated using orthopantomograms (OPGs) from 90 subjects divided into three groups of 30 each: UCLP group, non-cleft skeletal Class III, and non-cleft skeletal Class I.
View Article and Find Full Text PDFEffect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats.
J Oral Biol Craniofac Res
January 2025
Department of Dental Biomedical Sciences, Faculty of Dentistry, Universitas Gadjah Mada, Indonesia.
Background: Retention is an essential element of orthodontic treatment. In the past two decades, numerous biological treatments have been developed to alleviate orthodontic relapse. Pharmacologic bone modulation is a viable approach to mitigate relapse.
View Article and Find Full Text PDFPodoplanin expression in various types of oral dysplasia and oral squamous cell carcinoma.
J Taibah Univ Med Sci
February 2025
Shahid Beheshti University of Medical Sciences, Faculty of Dentistry, Department of Oral & Maxillofacial Pathology, Tehran, Iran.
Objective: This study was aimed at investigating the roles of podoplanin (PDPN) as a marker associated with malignant development, progression, and poor prognosis in oral leukoplakia and various forms of oral squamous cell carcinoma (OSCC), particularly in relation to the extent of invasion.
Methods: Immunohistochemical analysis of PDPN was conducted on 77 histologically confirmed, formalin-fixed, paraffin-embedded samples representing various degrees of OSCC invasion and dysplasia grades.
Results: The samples were analyzed with Fisher's exact test and the Kruskal-Wallis test.
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