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| http://dx.doi.org/10.3201/eid2107.150178 | DOI Listing |
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Structural proteins of human coronaviruses: what makes them different?
Front Cell Infect Microbiol
December 2024
Biology Department, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Following COVID-19 outbreak with its unprecedented effect on the entire world, the interest to the coronaviruses increased. The causative agent of the COVID-19, severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2) is one of seven coronaviruses that is pathogenic to humans. Others include SARS-CoV, MERS-CoV, HCoV-HKU1, HCoV-OC43, HCoV-NL63 and HCoV-229E.
View Article and Find Full Text PDFA multi-antigen vaccinia vaccine broadly protected mice against SARS-CoV-2 and influenza A virus while also targeting SARS-CoV-1 and MERS-CoV.
Front Immunol
December 2024
Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Introduction: Coronaviruses and influenza viruses are significant respiratory pathogens that cause severe disease burdens and economic losses for society. Due to their diversity and evolution, vaccines typically require periodic updating to remain effective. An additional challenge is imposed by the possible coinfection of SARS-CoV-2 and influenza, which could increase disease severity.
View Article and Find Full Text PDFBroad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans.
NPJ Vaccines
October 2024
College of Basic Medical Sciences, Hengyang Medical School, University of South China & MOE Key Lab of Rare Pediatric Diseases, Hengyang, 421001, China.
The outbreaks of severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2 highlight the need for countermeasures to prevent future coronavirus pandemics. Given the unpredictable nature of spillover events, preparing antibodies with broad coronavirus-neutralizing activity is an ideal proactive strategy. Here, we investigated whether SARS-CoV-2 infection and vaccination could provide cross-neutralizing antibodies (nAbs) against zoonotic sarbecoviruses.
View Article and Find Full Text PDFCase report: Rare Guillain-Barré syndrome variants and mild encephalitis/encephalopathy with a reversible splenial lesion as the para-infectious manifestations of SARS-CoV-2 infection.
Front Immunol
October 2024
Department of Neurology, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.
Article Synopsis
- The case study discusses a 32-year-old woman diagnosed with Guillain-Barré syndrome (GBS) linked to SARS-CoV-2, presenting unique neurological symptoms like cranial nerve dysfunction and autonomic issues.
- After receiving treatment, her inflammatory markers and sodium levels normalized, although some symptoms like fatigue and speech difficulties persisted after nine months.
- This highlights the complex neurological effects of COVID-19, indicating a need for further research into its underlying mechanisms and treatment options for affected patients.
A Comparison between Demyelinating and Omicron Variant Infection-Associated Optic Neuritis.
Discov Med
September 2024
Centre for Ophthalmology and Visual Science (Lions Eye Institute), The University of Western Australia, Nedlands, WA 6009, Australia.
Article Synopsis
- The study investigates the differences between optic neuritis (ON) caused by the Omicron variant of SARS-CoV-2 and spontaneous demyelinating ON, focusing on clinical features and cerebrospinal fluid (CSF) characteristics.
- Fifteen patients with Omicron-related ON and fifteen control patients with demyelinating ON were compared, revealing higher ocular pain and peripapillary hemorrhages in the Omicron group, along with elevated white cell counts in CSF.
- The findings suggest Omicron-related ON presents with more severe symptoms and distinct CSF profiles, supporting steroid treatment while highlighting the need for tailored approaches in managing these conditions.
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